Identification and verification of ferroptosis-related genes in gastric intestinal metaplasia

Song, Biao; Li, Tingting; Zhang, Yi; Yang, Qi; Pei, Bei; Liu, Yun; Wang, Jieyu; Dong, Gang; Sun, Qin; Fan, Shanshan; Li, Xuejun

doi:10.3389/fgene.2023.1152414

Cited by 4 publications

(1 citation statement)

References 39 publications

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“…Some studies have shown reduced CD4 and CD8 T lymphocytes with advancements along the Correa cascade, suggestive of altered immune surveillance, but there have been variations in this trend [125][126][127]. Song et al profiled the immune environment using CIBERSORT to show that the proportion of regulatory T lymphocytes and undifferentiated (M0) macrophages was higher than normal controls, while the proportion of CD4 memory T lymphocytes and dendritic cells was lower [128]. The interaction of these cells with each other and IM warrants further investigation, as well as the intersection with the specific immune response to H. pylori [129,130].…”

Section: Microbiome and The Immune Landscapementioning

confidence: 99%

Gastric Intestinal Metaplasia: Challenges and the Opportunity for Precision Prevention

Tjandra

Busuttil

Boussioutas

2023

Cancers

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GIM is a persistent, premalignant lesion whereby gastric mucosa is replaced by metaplastic mucosa resembling intestinal tissue, arising in the setting of chronic inflammation, particularly in the context of Helicobacter pylori. While the overall rates of progression to gastric adenocarcinoma are low, estimated at from 0.25 to 2.5%, there are features that confer a much higher risk and warrant follow-up. In this review, we collate and summarise the current knowledge regarding the pathogenesis of GIM, and the clinical, endoscopic and histologic risk factors for cancer. We examine the current state-of-practice with regard to the diagnosis and management of GIM, which varies widely in the published guidelines and in practice. We consider the emerging evidence in population studies, artificial intelligence and molecular markers, which will guide future models of care. The ultimate goal is to increase the detection of early gastric dysplasia/neoplasia that can be cured while avoiding unnecessary surveillance in very low-risk individuals.

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Section: Microbiome and The Immune Landscapementioning

confidence: 99%

Gastric Intestinal Metaplasia: Challenges and the Opportunity for Precision Prevention

Tjandra

Busuttil

Boussioutas

2023

Cancers

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Regulatory mechanisms and potential therapeutic targets in precancerous lesions of gastric cancer: A comprehensive review

Zhang,

Zhong,

Song

et al. 2024

Biomedicine & Pharmacotherapy

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Сharacterization of the immune microenvironment’s cellular composition and its influence on gene expression during metaplastic changes of the gastric mucosa epithelium

Slepov,

Emelin,

Deev

2024

Morphology

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Rationale. Intestinal metaplasia of gastric mucosa epithelium in chronic atrophic gastritis is considered by most authors as a precancerous condition, but it is potentially reversible. The study of the regulation mechanisms of metaplastic epithelial changes development may become the key in understanding the process of carcinogenesis and prevention of cancer development. Objective. To determine whether there is a relationship between microenvironment and development of metaplasia of gastric mucosa epithelium of patients with chronic atrophic gastritis by assessing gene expression and cellular composition of immune infiltrate. Materials and Methods. A retrospective cohort study, the alternative hypothesis of which is that the composition of the gastric mucosa immune microenvironment differs between cases with and without metaplastic changes in the epithelium. Biopsy specimens of the mucosa (n = 38) obtained during endoscopic examination from five sites (2 from the antrum, 2 from the body, 1 from the corner) of the stomach of patients with chronic atrophic gastritis of unspecified etiology, as well as the results of RNA sequencing isolated from biopsy specimens of patients with chronic gastritis obtained from the NCBI open database (n = 12) served as the material for the study. Histological, histochemical staining methods, immunohistochemical study were applied during the study. Morphometric, statistical and bioinformatic analyses were performed. Results. It was found that the proportion of macrophages, T-cytotoxic lymphocytes and plasmocytes was increased in the samples with metaplastic changes of the gastric mucosa epithelium. A correlation between T-cytotoxic lymphocytes and the chance of metaplasia development was found. It was found that changes in the number of T-helper cells, T-cytotoxic lymphocytes, T-regulatory cells and plasmocytes are associated with changes in the expression of five genes most specific for intestinal-type epithelium. Conclusion. The significant difference in the composition of the immune microenvironment between samples with and without metaplastic changes in the mucosal epithelium indicates the potential influence of immune cells on the development of metaplasia and progression of the pathological process along the Correa cascade. One of the mechanisms of regulation of metaplasia development by microenvironment may be their influence on gene expression as an epigenetic factor.

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Identification and verification of ferroptosis-related genes in gastric intestinal metaplasia

Cited by 4 publications

References 39 publications

Gastric Intestinal Metaplasia: Challenges and the Opportunity for Precision Prevention

Gastric Intestinal Metaplasia: Challenges and the Opportunity for Precision Prevention

Regulatory mechanisms and potential therapeutic targets in precancerous lesions of gastric cancer: A comprehensive review

Сharacterization of the immune microenvironment’s cellular composition and its influence on gene expression during metaplastic changes of the gastric mucosa epithelium

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