The climatically unfavourable period of the Last Glacial Maximum (LGM; ca. 26–19 ka cal bp) is held responsible for a severe demographic crisis of hunter–gatherer populations, their retreat to a few refugial areas, the disruption of wide-ranging networks, and a considerable loss of cultural complexity in Eastern and Central Europe. The latitudes above 50°N appear to have been completely depopulated. Recent research has demonstrated a continuous occupation of the Carpathian Basin and the East Carpathian region during the LGM on one hand, and an ephemeral human presence in the Middle Danube, the Middle Rhine, and the Swiss Plateau on the other. The western part of the East European Plain, in particular the East Carpathians, is known for several large, Early Epigravettian open-air sites with well-preserved artefacts of antler, bone, and mammoth ivory. For Central Europe, the assemblage from Kammern-Grubgraben in Lower Austria is of pivotal importance. As osseous industries have shown to be an essential component of Upper Palaeolithic material culture, it is the aim of this contribution to provide an overview of the current state of knowledge on the processing of hard animal tissues in Eastern and Central Europe during the LGM. Starting out with a reevaluation of one of the largest and most diverse assemblages from the site of Cosăuţi in the Republic of Moldova (ca. 23–19 ka cal bp), contemporary assemblages from the area between the Bug River in the east and the Rhine in the west are presented, discussed and compared with the situation in Western Europe. Based on that, it can be asked what information osseous industries can provide about the development of technological traditions and dissemination of concepts during the LGM from a local and supraregional perspective.