Identification, epidemiological relatedness, and biofilm formation of clinical Chryseobacterium indologenes isolates from central Taiwan

Chang, Yi‐Cheng; Lo, Hsueh-Hsia; Hsieh, Hsiu-Ying; Chang, Shan-Min

doi:10.1016/j.jmii.2014.04.004

Cited by 41 publications

(42 citation statements)

References 21 publications

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“…Patients with Chryseobacterium infections usually have comorbidities, such as cardiovascular disease, malignancy, chronic kidney disease, diabetes mellitus, and chronic obstructive pulmonary disease (3)(4)(5)(6)(7)(8)(9)(10)(11). In our study, one or more comorbidities were recognized in 81.7% of Chryseobacterium-infected patients.…”

Section: Discussionmentioning

confidence: 50%

“…According to previous studies, Chryseobacterium commonly causes bacteremia, catheter-related infection, and pneumonia, and these infections are usually hospital acquired (3)(4)(5)(6)(7)(8)(9)(10)(11). Indeed, a previous study found that 47% (17/36) of C. indologenesinfected patients developed bacteremia (7), and in a study of 215 Chryseobacterium isolates (4), 64.2% and 18.1% were obtained from sputum and blood, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Information about the susceptibilities of Chryseobacterium to antimicrobial agents is limited. Previous studies have demonstrated that Chryseobacterium is usually resistant to ceftriaxone, aztreonam, carbapenems, and aminoglycosides but variably susceptible to piperacillin, piperacillin-tazobactam, ceftazidime, cefepime, minocycline, tigecycline, ciprofloxacin, levofloxacin, and trimethoprim-sulfamethoxazole (4)(5)(6)(7)(8)(9)(10)(11)(12). The study by Hsueh et al (7) reported that 75% (27/36) of C. indologenes isolates obtained in 1992 to 1995 were susceptible to minocycline, 63.9% were susceptible to piperacillin, 41.7% were susceptible to ceftazidime, and 30.6% were susceptible to trimethoprim.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, a significant difference in the susceptibility rates was found between C. gleum and C. indologenes, whereby C. gleum was significantly more susceptible to piperacillin, piperacillin-tazobactam, ceftazidime, tigecycline, and levofloxacin. Only a few studies to date have examined the antimicrobial susceptibility of Chryseobacterium using accurate identification methods (10,11). For example, Lo and Chang (10) and Chang et al (11) used 16S rRNA gene sequencing to identify Chryseobacterium species and reported the susceptibilities of 15 C. gleum and 34 C. indologenes strains as follows (in respective order): minocycline, 100% and 100%; trimethoprim-sulfamethoxazole, 93.3% and 52%; ciprofloxacin, 40% and 14.7%; piperacillin, 0 and 2.9%; and piperacillintazobactam, 0 and 2.9%.…”

Section: Discussionmentioning

confidence: 99%

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Differences in Clinical Manifestations, Antimicrobial Susceptibility Patterns, and Mutations of Fluoroquinolone Target Genes between Chryseobacterium gleum and Chryseobacterium indologenes

Lin

Lai

Yang

et al. 2019

Antimicrob Agents Chemother

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Chryseobacterium infections are uncommon, and previous studies have revealed that Chryseobacterium gleum is frequently misidentified as Chryseobacterium indologenes. We aimed to explore the differences in clinical manifestations and antimicrobial susceptibility patterns between C. gleum and C. indologenes. The database of a clinical microbiology laboratory was searched to identify patients with Chryseobacterium infections between 2005 and 2017. Species were reidentified using 16S rRNA gene sequencing, and patients with C. gleum and C. indologenes infections were included in the study. A total of 42 C. gleum and 84 C. indologenes isolates were collected from consecutive patients. A significant increase in C. indologenes incidence was observed. C. gleum was significantly more associated with bacteremia than C. indologenes. Patients with C. gleum infections had more comorbidities of malignancy and liver cirrhosis than those with C. indologenes infections. The overall case fatality rate was 19.8%. Independent risk factors for mortality were female sex and C. indologenes infection. These isolates were most susceptible to minocycline (73%), followed by trimethoprim-sulfamethoxazole (47.6%), tigecycline (34.1%), and levofloxacin (32.5%). C. gleum exhibited a significantly higher rate of susceptibility than C. indologenes to piperacillin, piperacillin-tazobactam, ceftazidime, tigecycline, and levofloxacin. Alterations in DNA gyrase subunit A were identified to be associated with fluoroquinolone resistance in C. indologenes. No nonsynonymous substitutions were observed in the quinolone resistance-determining regions (QRDRs) of C. gleum. Differences in epidemiology, clinical manifestations, and antimicrobial susceptibility patterns exist between C. gleum and C. indologenes. Additional investigations are needed to explore the significance of these differences.

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Differences in Clinical Manifestations, Antimicrobial Susceptibility Patterns, and Mutations of Fluoroquinolone Target Genes between Chryseobacterium gleum and Chryseobacterium indologenes

Lin

Lai

Yang

et al. 2019

Antimicrob Agents Chemother

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“…Its ability to produce biofilm on foreign materials and produce proteases, can cause several forms of infections and is responsible for its virulent character 31. One study mentioned the production of a metallo-β-lactamase, which allows the bacteria to hydrolyse the β lactam part of some drugs 32.…”

Section: Discussionmentioning

confidence: 99%

Chryseobacterium indologenes: an emerging infection in the USA

et al. 2016

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Nursing home-associated infections and antibiotic resistant pathogens constitute common and serious problems in the geriatric population.Chryseobacterium indologenes, a non-motile Gram-negative rod, though widely distributed in nature, is an uncommon human pathogen. Typically thought of as an organism of low virulence, it may cause serious infections, particularly among the immunocompromised. The majority of reported cases are nosocomial, often associated with immunosuppression or indwelling catheters. It has been reported as the causative agent in bacteraemia, peritonitis, pneumonia, empyema, pyelonephritis, cystitis, meningitis and central venous catheter-associated infections. We report a rare case of C. indologenesinfection affecting a nursing home resident in the USA and we provide a review of similar cases. This report emphasises the importance of individualised treatment and promotes awareness about this organism as one of several emerging pathogens in immunocompromised adults and in the frail elderly who are often nursing home residents, in the Western Hemisphere.

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Chryseobacterium

Hugo

Bernardet

Nicholson

et al. 2019

Bergey's Manual of Systematics of Archaea and Bacteria

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Chry.se.o.bac.te'ri.um. Gr. adj. chryseos golden; L. neut. n. bacterium a small rod; N.L. neut. n. Chryseobacterium a yellow rod. Bacteroidetes / Flavobacteriia / Flavobacteriales / Flavobacteriaceae / Chryseobacterium The genus Chryseobacterium is classified within the family Flavobacteriaceae , order Flavobacteriales , and in the class Flavobacteriia . Almost all species produce pale yellow to orange colonies, mainly due to flexirubin‐type pigments and sometimes carotenoid pigments. Cells are rod shaped and Gram‐staining‐negative. Most strains grow optimally at 15–30°C, pH 6–8, and 0–1% (w/v) NaCl, although halotolerant species do occur. Almost all species are strictly aerobic. Menaquinone‐6 is the major respiratory quinone. Phosphatidylethanolamine is the major polar lipid in most species. sym ‐homospermidine is the major polyamine, and phosphosphingolipids are absent. The major fatty acids are iso‐C 15:0 , iso‐C 17:1 ω9 c , iso‐C 17:0 3‐OH, and iso‐C 15:0 2‐OH. The type strains from most species were isolated from environmental sources such as fresh or seawater, or soil. Other sources include insects, plant rhizosphere, biofilms, surfaces in beer bottling plants, and other industrial sources. Human clinical specimens and hospital environments have yielded certain species as well as unclassified strains, but it is often unclear if they are direct pathogens, opportunistic pathogens, or mere contaminants. Similarly, Chryseobacterium isolates have been derived from both healthy and diseased fish. Several species occur in food or dairy products; they may be involved in spoilage. DNA G + C content (mol%) : 28.8–49.3. Type species : Chryseobacterium gleum (Holmes, Owen, Steigerwalt and Brenner 1984b) Vandamme, Bernardet, Segers, Kersters and Holmes 1994, 830 VP ( Flavobacterium gleum Holmes, Owen, Steigerwalt and Brenner 1984b, 23).

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Identification, epidemiological relatedness, and biofilm formation of clinical Chryseobacterium indologenes isolates from central Taiwan

Cited by 41 publications

References 21 publications

Differences in Clinical Manifestations, Antimicrobial Susceptibility Patterns, and Mutations of Fluoroquinolone Target Genes between Chryseobacterium gleum and Chryseobacterium indologenes

Differences in Clinical Manifestations, Antimicrobial Susceptibility Patterns, and Mutations of Fluoroquinolone Target Genes between Chryseobacterium gleum and Chryseobacterium indologenes

Chryseobacterium indologenes: an emerging infection in the USA

Chryseobacterium

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