Identification of 1,3-thiazole-5-carboxylic Acid Derivatives as Inhibitors of Protein Kinase CK2

The synthesis of 5-hetarylamino-3-aryl-1H-indazoles as inhibitors of protein kinase CK2

“…The search for CK2 inhibitors has been carried out for over 20 years [9,10]. Most of the identified CK2 inhibitors belong to coumarins [11], halogenated benzimidazoles (ТВВ) [12], anthraquinones (emodin) [13], indoloquinazolines (IQA) [14], thieno [2,3-d] pyrimidines [15,16], 4,5,6,7-tetrahalogeno-1H-isoindole-1,3(2H)-diones [17], flavones derivatives (luteolin, FLC26, FNH79) [18][19][20], 1,3-thiazole-5-carboxylic acid derivatives [21], quinolones [22], aurones [23,24] and naphthyridines (CX-4945, CX-5011) [25,26].…”