Identification of 58 novel HLA alleles identified in Chinese individuals by next‐generation sequencing

Abstract

HLA genes are the most polymorphic in the human genome. High resolution HLA typing from 13,870 bone marrow donors in Hong Kong was obtained using Next‐generation sequencing (NGS) technology. Among the 67 novel alleles identified, official HLA allele names of 50 novel class I alleles (HLA‐A, ‐B, ‐C) and 8 novel class II alleles (HLA‐DRB1, ‐DQB1) were assigned by the World Health Organization (WHO) Nomenclature Committee for Factors of the HLA System.

Nomenclature for factors of the HLA system, update July, August and September 2023

“…Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. An additional 140 alleles were recently published but have not been included in Table 3 due to space considerations 3,4 …”

“…An additional 140 alleles were recently published but have not been included in Table 3 due to space considerations. 3,4 All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IPD-IMGT/ HLA Database using the sequence submission tool provided. 5 The IPD-IMGT/HLA Database may be accessed via the World Wide Web at: www.ebi.ac.uk/ ipd/imgt/hla…”

Nomenclature for factors of the HLA system, update July, August and September 2023

“…Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. An additional 140 alleles were recently published but have not been included in Table 3 due to space considerations (Cheung et al, 2023;Pagkrati et al, 2023).…”