Identification of 5α‐reductase isoenzymes in canine skin

Souza, Lucilene Bernardi de; Paradis, Manon; Zamberlam, Gustavo; Benoit‐Biancamano, Marie‐Odile; Price, Christopher A.

doi:10.1111/vde.12234

Cited by 5 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…19 The alteration of the hair-cycle dynamics with an increase in the prevalence of kenogen follicles has been demonstrated in some canine non-inflammatory alopecias but not in pattern alopecia, 26 and the expression of 5-α-reductase genes has been evaluated in only one study, performed in normal skin. 27 In order to provide both qualitative and quantitative diagnostic follicular information, transverse sections of skin biopsy specimens were used in this study, as in human literature. 28,29 Some key information such as follicular counts was easily assessed, and histological findings were shown to positively correlate with dermoscopic calculations of hair parameters.…”

Section: Discussionmentioning

confidence: 99%

The usefulness of dermoscopy in canine pattern alopecia: a descriptive study

Zanna

Roccabianca

Zini

et al. 2017

Advances in Veterinary Dermatology

View full text Add to dashboard Cite

BACKGROUND: Dermoscopic studies evaluating noninflammatory, nonpruritic progressive alopecia attributable to pattern alopecia are currently unavailable. HYPOTHESIS/OBJECTIVES: To evaluate the dermoscopic features observed in healthy skin of short coated dogs and compare these findings with those observed in dogs affected by pattern alopecia diagnosed by clinical and dermatopathological examination. ANIMALS: Thirty male and female, healthy, breed matched, young adult, short coated dogs (controls) and 30 male and female, young adult, short coated dogs affected by pattern alopecia. METHODS: Dermoscopy was performed with a Fotofinder II videodermoscope equipped with software that allowed the measurement of structures visualized in magnified images (20×-40×-70×). Skin biopsy samples were obtained from the thorax and evaluated dermoscopically for dermoscopic-histological correlation in affected dogs. RESULTS: Dermoscopic findings in canine pattern alopecia were hair shaft thinning, circle hairs and follicular keratin plugs; in the affected sun exposed areas there was a honeycomb-like pattern of pigmentation. Arborizing red lines reflecting vascularization were classified as a nonspecific finding because they were also common in healthy dogs. Dermoscopic features correlated with histology for selected hair follicle abnormalities. CONCLUSIONS AND CLINICAL IMPORTANCE: Although canine pattern alopecia is a visually striking disease, this study supports the value of dermoscopy for clinical examination and also opens promising perspectives for the identification of diagnostic dermoscopic patterns that may be useful for other skin disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

The usefulness of dermoscopy in canine pattern alopecia: a descriptive study

Zanna

Roccabianca

Zini

et al. 2017

Advances in Veterinary Dermatology

View full text Add to dashboard Cite

show abstract

“…Leonardo Della Salda 1 | Laura Bongiovanni 1,2 | Marcella Massimini 1 | Mariarita Romanucci 1 | Antonella Vercelli 3 | Alessia Colosimo 4 | Ramona Di Matteo 1 | Sabrina Vanessa Patrizia Defourny 5 The p63 transcription factor plays a fundamental role in skin development and homeostasis. It is a key regulator of the proliferative potential of basal keratinocytes in mature epidermis, keratinocyte differentiation 7 and survival, 8 as well as other aspects of keratinocyte biology, including cell-cell adhesion, basement membrane formation and skin barrier integrity.…”

Section: O R I G I N a L A R T I C L E P63 Immunoexpression In Hair F...mentioning

confidence: 99%

“…Alopecia X affects Pomeranians and is an example of noninflammatory alopecia with suggested hereditary background. The pathogenesis of alopecia X has been studied extensively, yet it remains unclear 4,5 . A recent transcriptome profiling study of skin biopsies from Pomeranians affected by alopecia X revealed downregulation of key regulatory genes of the Wnt and Shh pathways, both crucial for the HC, a significant downregulation of the HF stem cell markers SOX9, LHX2, LGR5, TCF7L1 and GLI1 , and a slight downregulation of the TP63 gene 6 …”

Section: Introductionmentioning

confidence: 99%

p63 immunoexpression in hair follicles of normal and alopecia X‐affected skin of Pomeranian dogs

Della Salda,

Bongiovanni,

Massimini

et al. 2023

Veterinary Dermatology

View full text Add to dashboard Cite

BackgroundAlopecia X in Pomeranians is caused by a hair cycle deregulation, associated with downregulation of key regulatory genes of the Wnt and Shh pathways, and stem‐cell markers. However, the pathogenesis remains unclear. p63 is an important transcription factor correlated with the aforementioned hair cycle modulating genes.Hypothesis/ObjectivesThe aim of this study was to highlight possible changes of p63 immunohistochemical expression within the hair follicles in canine alopecia X compared with normal skin.AnimalsSkin biopsies from 19 alopecia X‐affected and six control Pomeranians were analysed.Materials and MethodsSerial histological sections of skin biopsies harbouring anagen, telogen and kenogen hair follicles were immunohistochemically evaluated for differences in p63 expression in the affected and control samples.ResultsDogs with alopecia X had a significantly decreased immunoexpression of p63 in telogen and kenogen hair follicles.Conclusions and Clinical RelevanceThe decrease of p63 immunoexpression observed in canine alopecia X suggests an involvement of p63 in hair cycle.

show abstract