Identification of a 3-(5-methyl-2-thiazolylamino)phthalide as a new minor groove agent

Yilmaz, Zeynep; Odabaşoğlu, Hakkı Yasin; Şenel, Pelin; Yüzbaşıoğlu, F. Elif; Erdoğan, Taner; Özdemir, Ayşe; Gölcü, Ayşegül; Odabaşoğlu, Mustafa; Büyükgüngör, Orhan

doi:10.1080/07391102.2022.2061595

Cited by 1 publication

(2 citation statements)

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“…A modified broth dilution assay in 96 wellmicroplate, described in detail in a previous paper of our group [30], has been used in the antibacterial activity analysis. Briefly, the stock solutions were prepared at 50 mg/mL in methanol from methanolic extracts of flower and peduncle parts of G. sagittalis.…”

Section: Minimal Inhibition Concentration (Mic) Analysismentioning

confidence: 99%

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Pharmacological Properties of <i>Genista sagittalis</i> L. (Fabaceae) Grown in Turkey

et al. 2023

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The genus Genista L. (Family: Fabaceae) is a plant having several traditional uses for treating common ailments such as diabetes, ulcer, and respiratory diseases. In this current study, the composition of essential oil and the biological activities of Genista sagittalis L. (Fabaceae) from Kocaeli: Yuvacık Dam Basin have been studied. A total of fourteen components were identified in the essential oil. The identified compounds belonged to straight-chain alkane, aromatic ether, and terpenoid derivatives. The antibacterial activity analyses demonstrated that G. sagittalis flower extract only had low activity against P. mirabilis and P. aeruginosa with MICs 1 to 2 mg/mL, as the peduncle extract showed strong anti-QS activity at 1.3 mg/mL. To the best of our knowledge, the current work is the first to report the antimicrobial and anti-quorum sensing activity of G. sagittalis growing in Turkey. Double-stranded DNA binding affinity investigations of the flower and peduncle ethanol extracts indicate that there are interactions with double-stranded DNA and related binding constants (Kb) were found as 1.97×103±0.37 and 3.68×102±0.44 for the flower and peduncle extract, respectively.

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Section: Minimal Inhibition Concentration (Mic) Analysismentioning

confidence: 99%

“…Anti-QS activity was analyzed by a modified broth dilution assay [30] in 96 well-microplate previously described using sub-MIC concentrations (1.0-1.9 mg/mL) with CV12472 biosensor strain. Kanamycin (100 μg/mL) was used as a standard antibiotic.…”

Section: Anti-qs Analysismentioning

confidence: 99%