1992
DOI: 10.1016/0888-7543(92)90159-p
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Identification of a CA repeat at the TCRA locus using yeast artificial chromosomes: A general method for generating highly polymorphic markers at chosen loci

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Cited by 38 publications
(12 citation statements)
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“…The potential role of five regions containing genes that could be involved in the response against malaria infection were investigated by linkage analysis with polymorphic markers: 1) The HLA-TNF region (6p21) through the Genethon (Evry, France) microsatellite marker D6S276; 17 2) the 2q13-q21 region including genes coding for interleukin-1 (IL-1) ␣ and ␤ through an IL-1␣ intragenic marker; 18 3) the locus in 14q11 coding for the alpha chain of T cell antigen receptor through an intragenic T cell receptor (TCR␣) marker; 19 4) the gene cluster for the beta subunit of T cell receptor on chromosome 7q35 through an intragenic TCR␤ marker; 20 5) the last region was 5q31-q33, which contains several candidate genes as those coding for the granulocyte-macrophage colony-stimulating factor (CSF2), IL-3, IL-4, IL-5, IL-9, the immune regulatory factor 1 (IRF1), and the colonystimulating factor-1 receptor (CSF-1R). Six markers of this region were typed for the present analysis including four Genethon microsatellite markers (D5S393, D5S434, D5S436, and D5S636) 17 and two intragenic markers IL-9 21 and CSF1R.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The potential role of five regions containing genes that could be involved in the response against malaria infection were investigated by linkage analysis with polymorphic markers: 1) The HLA-TNF region (6p21) through the Genethon (Evry, France) microsatellite marker D6S276; 17 2) the 2q13-q21 region including genes coding for interleukin-1 (IL-1) ␣ and ␤ through an IL-1␣ intragenic marker; 18 3) the locus in 14q11 coding for the alpha chain of T cell antigen receptor through an intragenic T cell receptor (TCR␣) marker; 19 4) the gene cluster for the beta subunit of T cell receptor on chromosome 7q35 through an intragenic TCR␤ marker; 20 5) the last region was 5q31-q33, which contains several candidate genes as those coding for the granulocyte-macrophage colony-stimulating factor (CSF2), IL-3, IL-4, IL-5, IL-9, the immune regulatory factor 1 (IRF1), and the colonystimulating factor-1 receptor (CSF-1R). Six markers of this region were typed for the present analysis including four Genethon microsatellite markers (D5S393, D5S434, D5S436, and D5S636) 17 and two intragenic markers IL-9 21 and CSF1R.…”
Section: Methodsmentioning
confidence: 99%
“…22 Polymerase chain reaction primers were obtained from Genethon, 17 except for IL-1␣, 18 TCR␣, 19 TCR␤, 20 IL-9, 21 and CSF1R. 21 Genotypes were determined from two independent readings of each autoradiograph.…”
Section: Methodsmentioning
confidence: 99%
“…The degree of linkage disequilibrium across the TCR–α/δ locus is low [50], and the microsatellite has only been localised within a 900–kb yeast artificial chromosome [51]. The observed linkage may therefore be with any elements of TCR–α or TCR–δ, or with other genes in the locality.…”
Section: Genes Influencing Specific Ige Responses To Particular Allementioning
confidence: 99%
“…Current widely used methods for the identification of new simple sequence repeat polymorphisms involve PCRbased and subcloning strategies (1,2). Subcloning, once the primary method of isolating new microsatellite sequences (3), largely has been supplanted by PCR-based methods because of the relatively large amount of work and technical difficulties involved in subcloning strategies, including sublibrary construction and screening with oligonucleotide probes (4,5). PCR-based strategies, although generally faster and more successful than those using subcloning, still suffer from several disadvantages.…”
mentioning
confidence: 99%