1999
DOI: 10.1002/(sici)1521-4141(199909)29:09<2886::aid-immu2886>3.0.co;2-a
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Identification of a cross-reactive self ligand in virus-mediated autoimmunity

Abstract: Molecular mimicry has been considered to be one of the potential mechanisms underlying the induction of autoimmune diseases. Using a TCR‐transgenic model specific for lymphocytic choriomeningitis virus (LCMV) we have examined the potential for cross‐reactive recognition of tissue‐restricted self peptides. Several peptides were identified that were able to cross‐react with the TCR‐transgenic virus‐specific T cells in vitro. One peptide was derived from dopamine β‐mono‐oxygenase, an enzyme expressed in the adren… Show more

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Cited by 36 publications
(36 citation statements)
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“…We determine their binding avidities and half-lives as multimers. We show a good correlation between these results and previously reported characteristics of each peptide as an agonist, weak agonist, or antagonist and either positive or negative selector (27)(28)(29)(30)(31)(32)(33). In most cases, the negative selecting peptides have a longer half-life and higher avidity than the positive selectors.…”
supporting
confidence: 83%
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“…We determine their binding avidities and half-lives as multimers. We show a good correlation between these results and previously reported characteristics of each peptide as an agonist, weak agonist, or antagonist and either positive or negative selector (27)(28)(29)(30)(31)(32)(33). In most cases, the negative selecting peptides have a longer half-life and higher avidity than the positive selectors.…”
supporting
confidence: 83%
“…A representative experiment of three to four performed for each APL tetramer is shown. (29), and h (32). RMA-S stabilization data are derived from …”
Section: Tcr Down-regulation Assaymentioning
confidence: 99%
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