2015
DOI: 10.1111/tpj.12954
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Identification of a flavin‐containing S‐oxygenating monooxygenase involved in alliin biosynthesis in garlic

Abstract: SUMMARYS-Alk(en)yl-L-cysteine sulfoxides are cysteine-derived secondary metabolites highly accumulated in the genus Allium. Despite pharmaceutical importance, the enzymes that contribute to the biosynthesis of S-alk-(en)yl-Lcysteine sulfoxides in Allium plants remain largely unknown. Here, we report the identification of a flavin-containing monooxygenase, AsFMO1, in garlic (Allium sativum), which is responsible for the S-oxygenation reaction in the biosynthesis of S-allyl-L-cysteine sulfoxide (alliin). Recombi… Show more

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Cited by 68 publications
(64 citation statements)
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“… and Yoshimoto et al. pathways for synthesis of organosulfur compounds in garlic are proposed in this study as supplementary information (see Supporting Information Fig. ) to interpret metabolic changes occurring during fermentation.…”
Section: Resultsmentioning
confidence: 97%
“… and Yoshimoto et al. pathways for synthesis of organosulfur compounds in garlic are proposed in this study as supplementary information (see Supporting Information Fig. ) to interpret metabolic changes occurring during fermentation.…”
Section: Resultsmentioning
confidence: 97%
“…Phylogenetic analyses based on protein sequences have divided plant FMOs into three clades (Olszak et al ., ; Schlaich, ; Yoshimoto et al ., ). Arabidopsis FMO1 falls into clade I; as described above it monooxygenates the N–H group in the piperidine ring of Pip to generate the N ‐hydroxylated amino acid NHP (Figure a).…”
Section: N‐oxygenation Reactions In Plants and Other Organismsmentioning
confidence: 97%
“…The name A. fistulosum comes from the fact that the leaves are hollow, ("fistulosum" means "hollow"). Allium species are rich in two secondary metabolites that have perceived health benefits (YOSHIMOTO et al, 2015). These are the flavonoids (quercetin, anthocyanins and allixin) and the odorless organosulphur compounds, alk (en)yl cysteine sulphoxides (ACSOs).…”
Section: Introductionmentioning
confidence: 99%