1991
DOI: 10.1016/0092-8674(91)90397-h
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Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

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Cited by 3,178 publications
(1,948 citation statements)
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References 24 publications
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“…3. Our restriction map of the clones coincided to the ones which have been constructed on the D N A fragments derived from yeast artificial chromosome (YAC) clones spanning the fragile X breakpoint (Verkerk et al, 1991;Yu et aI., 1991;Kremer et al, 1991). The chromosomal location of the genomic clones isolated here were further confirmed by fluorescence in situ hybridization to localize at the expressed site of the fragile X chromosome (data not shown).…”
Section: Polymerase Chain Reactionsupporting
confidence: 73%
“…3. Our restriction map of the clones coincided to the ones which have been constructed on the D N A fragments derived from yeast artificial chromosome (YAC) clones spanning the fragile X breakpoint (Verkerk et al, 1991;Yu et aI., 1991;Kremer et al, 1991). The chromosomal location of the genomic clones isolated here were further confirmed by fluorescence in situ hybridization to localize at the expressed site of the fragile X chromosome (data not shown).…”
Section: Polymerase Chain Reactionsupporting
confidence: 73%
“…FXS is the most common inherited cause of intellectual disability, occurring in 1 in 4,000 males and 1 in 8,000 females [706], and is caused by a mutation of the FMR1 gene on the long arm of the X chromosome(locus Xq27.3; [707]). The FMR1 full mutation affects cognition, adaptive behavior, social abilities, and motor skills [708].…”
Section: Reviewmentioning
confidence: 99%
“…Especially, molecular cloning of autosomal rare fragile site, as has been done in fra(X)(q27.3) (Verkerk et al, 1991;Kremer et al, 1991) is an essential step not only for understanding of fragile site itself, but also for chromosomal instability of human genome.…”
Section: Fra(17)(p12) 10 / 16mentioning
confidence: 99%