Identification of a group of brominated flame retardants as novel androgen receptor antagonists and potential neuronal and endocrine disrupters

Kharlyngdoh, Joubert Banjop; Pradhan, Ajay; Asnake, Solomon; Walstad, Anders; Ivarsson, Per; Olsson, Per‐Erik

doi:10.1016/j.envint.2014.09.002

Cited by 36 publications

(23 citation statements)

References 60 publications

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“…Degradation of BRF emits vapors that have negative health impacts. Studies have shown that BFR has endocrine disrupting effects (44), neurotoxic effects (45), and causes tissue accumulation (46). However, limited toxicity information is present, and results are mostly incomplete and often conflicting.…”

Section: Indoor Air Pollutants -Sources and Health Effectsmentioning

confidence: 99%

Indoor air pollution and the contribution of biosensors

Eltzov

Cesarea²,

Low

et al. 2019

The EuroBiotech Journal

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A vast majority of people today spend more time indoors than outdoors. However, the air quality indoors may be as bad as or even worse than the air quality outside. This is due to the continuous circulation of the same air without proper ventilation and filtration systems, causing a buildup of pollutants. As such, indoor air quality monitoring should be considered more seriously. Indoor air quality (IAQ) is a measure of the air quality within and around buildings and relates to the health and comfort of building occupants. To determine the IAQ, computer modeling is done to simulate the air flow and human exposure to the pollutant. Currently, very few instruments are available to measure the indoor air pollution index. In this paper, we will review the list of techniques available for measuring IAQ, but our emphasis will be on indoor air toxicity monitoring.

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Section: Indoor Air Pollutants -Sources and Health Effectsmentioning

confidence: 99%

Indoor air pollution and the contribution of biosensors

Eltzov

Cesarea²,

Low

et al. 2019

The EuroBiotech Journal

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“…The BFR exposures that trigger neural effects and behavioral changes in animals are comparable to the higher end of the range of concentrations found in some infants and toddlers (Costa and Giordano, 2007; Costa et al, 2009). Some neurotoxicity of BFRs comes from disrupting the L‐type amino acid transporter system, which has been implicated in several neural disorders (Kharlyngdoh et al, 2015). Oxidative stress and Ca ++ regulation have also been implicated (Dingemans et al, 2011; it is interesting to note that disruption of neural Ca ++ homeostasis is a known neurotoxic factor in traumatic brain injury).…”

Section: Basis Of Links Between Volatiles and Neurotoxic Risk Factorsmentioning

confidence: 99%

“…In particular, Nguon et al focus on cerebellar defects, altered startle responses and impaired fine motor coordination, which have each been reported in autism. Endocrine effects are also reported for brominated flame retardants and phthalates; both phthalates and BFRs modulate androgen receptors (Chen et al, 2014; Costa and Giordano, 2007; Costa et al, 2009; Kharlyngdoh et al, 2015; Patisaul et al, 2015; Pradhan et al, 2013, 2015) and may modulate developmental effects in a sex‐specific manner (Chevrier et al, 2016; Lilienthal et al, 2006; Nguon et al, 2005; Patisaul et al, 2015; Swan et al, 2010). Lilienthal et al (2006) found PBDE exposures during pregnancy affected male rats much more than female rates, with sex differential effects in levels of circulating sex hormones, changes in physical development and behavior.…”

Section: Basis Of Links Between Volatiles and Neurotoxic Risk Factorsmentioning

confidence: 99%

Developmental neurotoxicity and autism: A potential link between indoor neuroactive pollutants and the curious birth order risk factor

Gray

Billock²

2017

Intl J of Devlp Neuroscience

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Epidemiological and demographic studies find an increased risk of autism among first-borns. Toxicological studies show that some semi-volatile substances found in infant products produce adverse effects in neural and endocrine systems of animals, including behavioral and developmental effects. Several factors elevate the exposure of human infants to these chemicals. The highest exposures found in infants are comparable to the exposures that induce neural toxicity in animals. A review of these literatures suggests a linking hypothesis that could bridge the epidemiological and toxicological lines of evidence: an infant's exposure to neuroactive compounds emitted by infant products is increased by product newness and abundance; exposure is likely maximized for first-born children in families that can afford new products. Exposure is reduced for subsequently-born children who reuse these now neuroactive-depleted products. The presence of neuroactive chemical emissions from infant products has implications for birth-order effects and for other curious risk factors in autism, including gender, socioeconomic status, and season-of-birth risk factors.

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“…EDs can disrupt the endocrine system through different mechanisms [ 7 , 8 , 9 , 10 , 11 , 12 ]. One of the well-known mechanisms is mediated by the hormone receptors such estrogen receptor (ER) and androgen receptor (AR), in which EDs exhibit their estrogenic and androgenic effects through binding to the ER and AR in the target cells [ 13 , 14 , 15 , 16 ]. Therefore, a huge amount of estrogenic and androgenic activity data of structurally diverse chemicals have been generated and organized in sophisticated databases such as the FDA’s Endocrine Disruptors Knowledge Base (EDKB) [ 17 ] and Estrogenic Activity Database (EADB) [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

A Rat α-Fetoprotein Binding Activity Prediction Model to Facilitate Assessment of the Endocrine Disruption Potential of Environmental Chemicals

Hong

Shen

et al. 2016

IJERPH

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Endocrine disruptors such as polychlorinated biphenyls (PCBs), diethylstilbestrol (DES) and dichlorodiphenyltrichloroethane (DDT) are agents that interfere with the endocrine system and cause adverse health effects. Huge public health concern about endocrine disruptors has arisen. One of the mechanisms of endocrine disruption is through binding of endocrine disruptors with the hormone receptors in the target cells. Entrance of endocrine disruptors into target cells is the precondition of endocrine disruption. The binding capability of a chemical with proteins in the blood affects its entrance into the target cells and, thus, is very informative for the assessment of potential endocrine disruption of chemicals. α-fetoprotein is one of the major serum proteins that binds to a variety of chemicals such as estrogens. To better facilitate assessment of endocrine disruption of environmental chemicals, we developed a model for α-fetoprotein binding activity prediction using the novel pattern recognition method (Decision Forest) and the molecular descriptors calculated from two-dimensional structures by Mold2 software. The predictive capability of the model has been evaluated through internal validation using 125 training chemicals (average balanced accuracy of 69%) and external validations using 22 chemicals (balanced accuracy of 71%). Prediction confidence analysis revealed the model performed much better at high prediction confidence. Our results indicate that the model is useful (when predictions are in high confidence) in endocrine disruption risk assessment of environmental chemicals though improvement by increasing number of training chemicals is needed.

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Identification of a group of brominated flame retardants as novel androgen receptor antagonists and potential neuronal and endocrine disrupters

Cited by 36 publications

References 60 publications

Indoor air pollution and the contribution of biosensors

Indoor air pollution and the contribution of biosensors

Developmental neurotoxicity and autism: A potential link between indoor neuroactive pollutants and the curious birth order risk factor

A Rat α-Fetoprotein Binding Activity Prediction Model to Facilitate Assessment of the Endocrine Disruption Potential of Environmental Chemicals

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