Identification of a Host-Targeted Compound to Control Typhoid Fever

Hoang, Ky V.; Woolard, Katherine; Yang, Ching; Melander, Christian

doi:10.1128/spectrum.00619-22

Cited by 1 publication

(1 citation statement)

References 48 publications

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“…Furthermore, host-directed therapy may also improve the defense mechanisms while simultaneously reducing the effects of exacerbated inflammation [116,117]. Moreover, the combination of host-directed therapies with pathogen-directed treatments, like antibiotics or antimicrobial peptides, makes it possible to synergize the beneficial effects of both therapeutics, thereby decreasing the drug dose administrated, minimizing its toxicity, and avoiding antimicrobial drug resistance [118][119][120].…”

Section: Circulating Ferritin As a New Therapeutic Strategymentioning

confidence: 99%

New Perspectives on Circulating Ferritin: Its Role in Health and Disease

Fonseca,

Ramos,

Gomes

et al. 2023

Molecules

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The diagnosis of iron disturbances usually includes the evaluation of serum parameters. Serum iron is assumed to be entirely bound to transferrin, and transferrin saturation—the ratio between the serum iron concentration and serum transferrin—usually reflects iron availability. Additionally, serum ferritin is commonly used as a surrogate of tissue iron levels. Low serum ferritin values are interpreted as a sign of iron deficiency, and high values are the main indicator of pathological iron overload. However, in situations of inflammation, serum ferritin levels may be very high, independently of tissue iron levels. This presents a particularly puzzling challenge for the clinician evaluating the overall iron status of the patient in the presence of an inflammatory condition. The increase in serum ferritin during inflammation is one of the enigmas regarding iron metabolism. Neither the origin, the mechanism of release, nor the effects of serum ferritin are known. The use of serum ferritin as a biomarker of disease has been rising, and it has become increasingly diverse, but whether or not it contributes to controlling the disease or host pathology, and how it would do it, are important, open questions. These will be discussed here, where we spotlight circulating ferritin and revise the recent clinical and preclinical data regarding its role in health and disease.

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