Identification of a hypoxia-associated long non-coding RNA signature and nomogram as a prognostic target for clear cell renal cell carcinoma

Abstract

Background To develop a hypoxia-associated long non-coding (lncRNA) signature for risk stratification in clear cell renal cell carcinoma (ccRCC). Methods The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma (TCGA KIRC) dataset was downloaded and analyzed. Results Four prognostic hypoxia-associated lncRNAs were used for signature construction. The four lncRNAs were downregulated in high grade, advanced stage, and high-risk ccRCC. ccRCC patients in the high-risk group had a worse prognosis than those in the low-risk group. And the risk score was significantly higher in high grade and advanced stage. The signature had an independent and long-standing prognosis prediction ability up to 10-year follow-up. Notably, the risk score was significantly positively correlated with the infiltration abundances of six immune cells from the Tumor IMmune Estimation Resource (TIMER). The gene set enrichment analysis (GSEA) also suggested that the signature was involved in the metabolism and tumorigenesis, which were closely related to the hypoxic tumor microenvironment. Ultimately, a nomogram was built to predict the individual long-term survival possibility. Conclusions We have developed a new hypoxia-associated lncRNA signature, representing a promising tool for risk stratification tool in ccRCC. It might serve as a prognostic index to facilitate personalized counseling for treatment.

Identification and Validation of Cuproptosis-Related Predictive Risk Signatures based on renal clear cell carcinoma

“…In addition to this, AC112220.2 has been confirmed as a Prognostic marker using the bioinformatics analysis of KIRC [21] . MYG1-AS1 had been construed in a hypoxia-related lncRNAs prognosis signature in hepatocellular carcinoma [22] . And AL161782.1 was a protective factor for KIRC but has not been reported.…”