Identification of a linear IgE inducing epitope on the SmATPDase1 surface

Emídio, Nayara Braga; Gusmão, Michélia Antônia do Nascimento; Borges, William Castro; Nakaie, Clóvis R.; Vasconcelos, Eveline Gomes; Pinto, Priscila de Faria

doi:10.1093/abbs/gmx031

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…In addition, S. mansoni ATP diphosphohydrolases (SmATPDases) also have allergenic properties [56], and some cysteine proteases of this parasite, such as cathepsin B1 (SmCB1), are similar to mite allergen Der p 1 [57,58]. Furthermore, IgE from infected individuals recognizes antigens from schistosomula, including the extracellular vesicle-enriched larval extracellular vesicle protein 1 (SmLEV1) [59].…”

Section: Schistosoma Sppmentioning

confidence: 99%

The Relationship of Parasite Allergens to Allergic Diseases

Caraballo

Llinás-Caballero

2023

Curr Allergy Asthma Rep

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Purpose of Review Helminth infections modify the natural history of allergic diseases, by either decreasing or increasing their symptoms. Several helminth components are involved in the increasing of the allergic response and symptoms, overcoming the concomitant immunosuppression of helminthiases. However, the role of individual IgE-binding molecules in this process remains to be defined. Recent Findings We updated the list of helminth allergens and IgE-binding molecules, their effects on asthma presentation, and their impact on allergy diagnosis. Data from genetic and epigenetic studies of ascariasis are analyzed. A new species-specific A. lumbricoides allergen has been discovered, with potential use in molecular diagnosis. Summary Most helminth IgE-binding components are not officially classified as allergens in the WHO/IUIS database, although there is evidence of their influence increasing allergic manifestations. Further immunological characterization of these components is needed to better understand their mechanisms of action and evaluate the ways in which they can influence the diagnosis of allergy.

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Section: Schistosoma Sppmentioning

confidence: 99%

The Relationship of Parasite Allergens to Allergic Diseases

Caraballo

Llinás-Caballero

2023

Curr Allergy Asthma Rep

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IgE antibodies from schistosomiasis patients to recognize epitopes in potato apyrase

Gusmão

Emídio

Marconato

et al. 2019

Rev. Soc. Bras. Med. Trop.

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Introduction: High percentages of structural identity and cross-immunoreactivity have been reported between potato apyrase and Schistosoma mansoni ATP diphosphohydrolase (SmATPDases) isoforms, showing the existence of particular epitopes shared between these proteins. Methods: Potato apyrase was employed using ELISA, western blot, and mouse immunization methods to verify IgE reactivity. Results: Most of the schistosomiasis patient's (75%) serum was seropositive for potato apyrase and this protein was recognized using western blotting, suggesting that parasite and plant proteins share IgE-binding epitopes. C57BL/6 mice immunized with potato apyrase showed increased IgE antibody production. Conclusions: Potato apyrase and SmATPDases have IgE-binding epitopes.

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Identification of a linear IgE inducing epitope on the SmATPDase1 surface

Cited by 2 publications

References 11 publications

The Relationship of Parasite Allergens to Allergic Diseases

The Relationship of Parasite Allergens to Allergic Diseases

IgE antibodies from schistosomiasis patients to recognize epitopes in potato apyrase

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