DOI: 10.26686/wgtn.17144027.v1
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Identification of a meningococcal adhesin that inhibits epithelial cell migration

Abstract: <p>Neisseria meningitidis virulence is polygenic, therefore comparing many genomes may not yield strictly disease-associated virulence factors. An alternative approach is comparing closely related isolates, such as those from household contacts. Disease isolates have been shown to inhibit epithelial cell wound repair, while many carriage isolates do not. In this study, bacteria collected from disease patients and healthy household contacts were compared to identify the meningococcal factor responsible fo… Show more

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