2022
DOI: 10.1097/md.0000000000028901
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Identification of a new RNA-binding proteins-based signature for prognostic prediction in gastric cancer

Abstract: Gastric cancer (GC) is one of the most common cancers with high incidence and mortality worldwide. Recently, RNA-binding proteins (RBPs) have drawn more and more attention for its role in cancer pathophysiology. However, the function and clinical implication of RBPs in GC have not been fully elucidated. RNA sequencing data along with the corresponding clinical information of GC patients were downloaded from The Cancer Genome Atlas (TCGA) database. Differentially expressed RNA-binding proteins (DERBPs) between … Show more

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Cited by 2 publications
(2 citation statements)
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“…To compare genes differentially expressed in PCa and NP groups, we performed differential expression analysis between groups by statistical tests using the R packages limma, pheatmap, and ggplot [ 15 , 16 ] based on the gene expression matrix of the training set. Results were presented in a heatmap and a volcano plot.…”
Section: Methodsmentioning
confidence: 99%
“…To compare genes differentially expressed in PCa and NP groups, we performed differential expression analysis between groups by statistical tests using the R packages limma, pheatmap, and ggplot [ 15 , 16 ] based on the gene expression matrix of the training set. Results were presented in a heatmap and a volcano plot.…”
Section: Methodsmentioning
confidence: 99%
“…Notably, these proteins are often dysregulated during carcinogenesis [ 10 ]. Based on their trigger function for the disease, RBP can serve as prognostic markers as well as potential therapeutic targets [ 11 15 ].…”
Section: Rna Binding Proteins and The Musashi Family – A Short Backgr...mentioning
confidence: 99%