Identification of a Novel Cell Type in Peripheral Lymphoid Organs of Mice

Abstract

During the course of observations on the cells of mouse spleen that adhere to glass and plastic surfaces, it was clear that this population was quite heterogeneous. In addition to mononuclear phagocytes, granulocytes, and lymphocytes, we noticed a large stellate cell with distinct properties from the former cell types. In this paper, we describe the morphology, quantitation, and tissue distribution of this novel cell as identified in vitro. In following papers, we will further characterize it with respect to its functional properties in vitro, as well as its localization and properties in situ. Materials and MethodsMice.--Outbred NCS mice were maintained at The Rockefeller University. Inbred DBA/2J, C3H, BALB/cJ, C57BL, and C57BL )< DBA/2J strains weIe obtained from the Jackson Laboratory, Bar Harbor, Maine. Mice, homo-and heterozygous at the nude locus, were kindly provided by Dr. P. Wernet of The Rockefeller University.

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