Identification of a novel chromosome region, 13q21.33-q22.2, for susceptibility genes in familial chronic lymphocytic leukemia

Abstract

Chronic lymphocytic leukemia (CLL) is

Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice

“…In our familial CLL studies, we find a variety of other lymphoid and hematologic malignancies. 3 Of greater interest, we find a significant increase of 13q14 deletions in familial CLL, 8 and thus the NZB may be a model not only for sporadic CLL but for familial CLL. This highlights the fact that additional factors influence the type of B-cell malignancy that develops.…”

“…6,7 A minimally deleted region (MDR) has been described, and several genes in this region have been sequenced, but no mutations in protein-coding regions have been identified. 8 However, mutations in mir-16 have been described, 9 as well as a reduction in the levels of expression in some patients with CLL. 10 The New Zealand black (NZB) mouse has been studied extensively as a model to investigate autoimmune diseases such as systemic lupus erythematosus (SLE) 11,12 as well as a model for the B-cell lymphoproliferative disorder CLL.…”

Polymorphisms in xenobiotic‐metabolizing genes and the risk of chronic lymphocytic leukemia and non‐Hodgkin's lymphoma in adult Russian patients

“…In the case of lymphomas, a family history of any hematopoietic malignancy was found to be associated with 2-3 fold increased risk of NHL [6,7]. Genome-wide linkage scans of CLL families revealed a number of chromosome bands with potential candidate genes, for example, 11p11 [8] and 13q22.1 [9]. The role and function of these candidate regions are under investigation now.…”

Genetic Variants in Apoptosis and Immunoregulation-Related Genes Are Associated with Risk of Chronic Lymphocytic Leukemia

“…However, genome-wide screening of families with CLL has not identified clear candidate genes (8)(9)(10)(11). Although part of the familial incidence of CLL could be due to high-penetrance mutations in unidentified genes, it seems plausible that common genetic variants with modest effects on disease susceptibility may be related to this risk.…”