Identification of a novel ferroptosis-related gene signature associated with retinal degeneration induced by light damage in mice

Lei, Xin-Lan; Yang, Qiao-Li; Wei, Yong-Zhao; Qiu, Xu; Zeng, Hui-Yi; Yan, Ai-Min; Peng, Kai; Li, Ying-Lin; Rao, Feng-Qin; Chen, Feng-Hua; Xiang, Lue; Wu, Kun-Chao

doi:10.1016/j.heliyon.2023.e23002

Cited by 2 publications

(1 citation statement)

References 65 publications

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“…Previously, the relationships between miR and diabetic retinopathy [17,18], oxygeninduced retinopathy [19], Müller glial cell function [20,21], light adaptation [22], and so on have been reported. Although α-Melanocyte-stimulating hormone was reported to reduce the excitotoxicity of chicken retinal neurons via the downregulation of miR-194 [23], little information has been shown about the relationship between miR and excitotoxicity of the mammalian retinal neuron.…”

Section: Discussionmentioning

confidence: 99%

The Role of microRNAs Related to Apoptosis for N-Methyl-d-Aspartic Acid-Induced Neuronal Cell Death in the Murine Retina

Sone,

Mori,

Sakamoto

et al. 2024

IJMS

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Glaucoma is one of the leading causes of acquired blindness and characterized by retinal ganglion cell (RGC) death. MicroRNAs are small noncoding RNAs that degrade their target mRNAs. Apoptosis is one of the common mechanisms leading to neuronal death in many neurodegenerative diseases, including glaucoma. In the present study, we identified microRNAs that modulate RGC death caused by the intravitreal injection of N-methyl-d-aspartic acid (NMDA). We found an upregulation of miR-29b and downregulation of miR-124 in the retina of the NMDA-injected eyes. The intravitreal injection of an miR-29b inhibitor 18 h before NMDA injection reduced RGC death and the downregulation of myeloid cell leukemia 1 (MCL-1), an anti-apoptotic factor, induced by intravitreal NMDA. The intravitreal injection of an miR-124 mimic 18 h before NMDA injection also reduced RGC death and the upregulation of B-cell/chronic lymphocytic leukemia lymphoma 2 (bcl-2)-associated X protein (Bax) and bcl-2 interacting protein (Bim), pro-apoptotic factors, induced by intravitreal NMDA. These data suggest that expressional changes in microRNA are involved in the excitotoxicity of RGCs, and that complement and/or inhibition of microRNA may be a potential therapeutic approach for the diseases related to the excitotoxicity of RGCs, such as glaucoma and retinal central artery occlusion.

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Section: Discussionmentioning

confidence: 99%

The Role of microRNAs Related to Apoptosis for N-Methyl-d-Aspartic Acid-Induced Neuronal Cell Death in the Murine Retina

Sone,

Mori,

Sakamoto

et al. 2024

IJMS

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Targeting ferroptosis: a novel therapeutic strategy for the treatment of retinal diseases

Hao,

Xu,

Zhang

et al. 2024

Front. Pharmacol.

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Ferroptosis plays a vital role in the progression of various retinal diseases. The analysis of the mechanism of retinal cell ferroptosis has brought new targeted strategies for treating retinal vascular diseases, retinal degeneration and retinal nerve diseases, and is also a major scientific issue in the field of ferroptosis. In this review, we summarized results from currently available in vivo and in vitro studies of multiple eye disease models, clarified the pathological role and molecular mechanism of ferroptosis in retinal diseases, summed up the existing pharmacological agents targeting ferroptosis in retinal diseases as well as highlighting where future research efforts should be directed for the application of ferroptosis targeting agents. This review indicates that ferroptosis of retinal cells is involved in the progression of age-related/inherited macular degeneration, blue light-induced retinal degeneration, glaucoma, diabetic retinopathy, and retinal damage caused by retinal ischemia-reperfusion via multiple molecular mechanisms. Nearly 20 agents or extracts, including iron chelators and transporters, antioxidants, pharmacodynamic elements from traditional Chinese medicine, ferroptosis-related protein inhibitors, and neuroprotective agents, have a remissioning effect on retinal disease in animal models via ferroptosis inhibition. However, just a limited number of agents have received approval or are undergoing clinical trials for conditions such as iron overload-related diseases. The application of most ferroptosis-targeting agents in retinal diseases is still in the preclinical stage, and there are no clinical trials yet. Future research should focus on the development of more potent ferroptosis inhibitors, improved drug properties, and ideally clinical testing related to retinal diseases.

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Identification of a novel ferroptosis-related gene signature associated with retinal degeneration induced by light damage in mice

Cited by 2 publications

References 65 publications

The Role of microRNAs Related to Apoptosis for N-Methyl-d-Aspartic Acid-Induced Neuronal Cell Death in the Murine Retina

The Role of microRNAs Related to Apoptosis for N-Methyl-d-Aspartic Acid-Induced Neuronal Cell Death in the Murine Retina

Targeting ferroptosis: a novel therapeutic strategy for the treatment of retinal diseases

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