Identification of a Novel Microsatellite Marker Tightly Linked to the KAI&amp;ndash;1 Gene for Predicting Prostate Cancer Progression

Maraj, BH; Leek, J.P.; Carr, IM; Markham, AF

doi:10.1159/000020123

Cited by 6 publications

(1 citation statement)

References 14 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, clinical studies indicate downregulation in 70% of primary prostate and loss of heterozygosity in an equivalent number of metastatic cases. At the present time, ongoing research has yet to clearly determine the precise molecular nature and mechanism of action of the metastasis suppressive properties of KAI1, which is most likely, a membrane bound receptor-type molecule mediating invasiveness, motility and cell signaling phenomena (Akita et al, 2000;Maraj et al, 2000).…”

Section: Kaimentioning

confidence: 99%

Molecular markers and determinants of prostate cancer metastasis

Gopalkrishnan

Kang

Fisher

2001

Journal Cellular Physiology

View full text Add to dashboard Cite

Although intensely studied, the molecular and biochemical determinants of prostate cancer development and progression remain ill-de®ned. Moreover, current markers and methodologies cannot distinguish between a tumor that will remain indolent and not impinge on patient survival, versus a tumor with aggressive traits culminating in metastatic spread and death. Once prostate cancer is con®rmed the most signi®cant threat to a patient's survival and quality of life involves tumor metastasis. Radical surgery notwithstanding, prostate cancer accounts for 10% of all cancer-related deaths primarily arising through development of metastasis. Metastasis markers demonstrating an acceptable level of reliability are an obvious necessity if disproportionate and costly treatment is to be avoided and a reasonably accurate determination of clinical prognosis and measure of successful response to treatment is to be made. Therapeutic strategies that speci®cally inhibit metastatic spread are not presently possible and may not become available in the immediate future. This is because, while localized tumorigenesis has been relatively amenable to detection, analysis and treatment, metastasis remains a relatively unde®ned, complex and underexplored area of prostate cancer research. New ®ndings in the ®eld such subclasses of genes called metastasis suppressors and cancer progression suppressors, have opened up exciting avenues of investigation. We review current methodological approaches, model experimental systems and genes presently known or having potential involvement in human prostate cancer metastasis.

show abstract

Section: Kaimentioning

confidence: 99%

Molecular markers and determinants of prostate cancer metastasis

Gopalkrishnan

Kang

Fisher

2001

Journal Cellular Physiology

View full text Add to dashboard Cite

show abstract

KAI-1 Protein Expression in Odontogenic Cysts

Iezzi

PIATTELLI²,

Artese

et al. 2007

Journal of Endodontics

View full text Add to dashboard Cite

The KAI-1 tumor suppressor gene is widely distributed in normal tissues and its down-regulation may be correlated with the invasive phenotype and metastases in several different epithelial tumors. The aim of the present study was an evaluation of KAI-1 expression in radicular cysts (RC), follicular cysts (FC), orthokeratinized keratocysts (OOKC), and parakeratinized keratocysts (POKC). Eighty-five odontogenic cysts, 28 RC, 22 FC, and 35 OKC (16 OOKC, 19 POKC) were selected. All the POKC were negative and only four of 16 of the OOKC were positive for KAI-1. On the contrary, all RC and FC cases were positive and immunoreactivity for KAI-1 was detected throughout all the layers of the cyst epithelium. The lack of KAI-1 expression in POKC could help to explain the differences in the clinical and pathologic behavior of OKC and, according to what has been reported for epithelial tumors, could be related to the increased aggressive behavior and invasiveness of OKC.

show abstract