Identification of a novel non-immunoglobulin/MYC translocation t(8;12)(q24;p12) involving the LRMP gene in a primary B-cell lymphoma. A case report

Singh, Rashmi; Ben-Neriah, Susana; Johnson, Nathalie; Connors, Joseph M.; Gascoyne, Randy D.; Horsman, Douglas E.

doi:10.1016/j.leukres.2011.09.020

Cited by 3 publications

(2 citation statements)

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“…Considering that LRMP is known to be expressed in germinal centre B-cells and in diffuse large B-cell Lymphomas of the “germinal” center subtype [12], we hypothesize that regulatory elements originally located upstream of the LRMP gene and juxtaposed to the MYC -locus, might be involved in the de-regulation of MYC . Interestingly, a recent report shows a case of a primary B-cell lymphoma with a t(8;12) translocation also involving MYC and LRMP [13]. Although the exact position of the breakpoint at LRMP was not determined, FISH analysis showed that the 5’ region of LRMP was translocated to the MYC locus also in this case.…”

Section: Resultsmentioning

confidence: 76%

Sequence based analysis of U-2973, a cell line established from a double-hit B-cell lymphoma with concurrent MYC and BCL2 rearrangements

et al. 2012

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BackgroundDouble-hit lymphoma is a complex and highly aggressive sub-type of B-cell lymphoma, which has recently been classified and is an area of active research interest due to the poor prognosis for patients with this disease. It is characterized by the presence of both an activating MYC chromosomal translocation and a simultaneous additional oncogenic translocation, often of the BCL2 gene. Recently, a cell line was established from a patient with this complex lymphoma and analyzed using conventional tools revealing it contains both MYC and BCL2 translocation events.FindingsIn this work, we reanalyzed the genome of the cell line using next generation whole genome sequencing technology in order to catalogue translocations, insertions and deletions which may contribute to the pathology of this lymphoma type.ConclusionsWe describe the cell line in much greater detail, and pinpoint the exact locations of the chromosomal breakpoints. We also find several rearrangements within cancer-associated genes, which were not found using conventional tools, suggesting that high throughput sequencing may reveal novel targets for therapy, which could be used concurrently with existing treatments.

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Section: Resultsmentioning

confidence: 76%

Sequence based analysis of U-2973, a cell line established from a double-hit B-cell lymphoma with concurrent MYC and BCL2 rearrangements

et al. 2012

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“…A V141L polymorphism of LRMP has been found associated with a higher mortality in patients with lung cancer (Manenti et al, 2006). LRMP has recently been found involved in a translocation t(8;12)(q24;p12) with a LRMP/MYC fusion gene in non Hodgkin lymphoma (Singh et al, 2012).…”

Section: P121mentioning

confidence: 99%

t(3;12)(q27;p12) LRMP/BCL6

Huret¹

2013

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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Current Perspectives in Genetics of “Double-Hit” Lymphoma with Possible Clinical Implications

Tan

Yuan

Guo

et al. 2013

Cell Biochem Biophys

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This article reviews particular subgroup of B-cell lymphoma, called "double-hit" lymphoma (DHL) because of its distinct aberrations-related genes influencing various processes such as apoptosis, differentiation, and proliferation. Recent studies indicate that tumorigenesis is a complex process involving multiple genes, genetic abnormalities, including gene mutations, deletions, and chromosomal alterations. Chromosomal aberrations are not affecting only basic cellular life preserving activities such as cell proliferation, differentiation, apoptosis, and signal transduction, but are also indispensible for evaluation of lymphoma occurrence, progression, and prognosis as well differential diagnosis and other aspects assessment. DHL is group accompanied by IGH-BCL2 and MYC rearrangement, behaving highly aggressively, with a complex and distinct karyotype which can not be extrapolated solely by morphological pathological assessment, since it has not been entirely characteristic. Therefore, we are reviewing possible effects of multiple genetic rearrangements, particular genes mutations, and developing hypothesis due which pathophysiology mechanisms DHL accomplish synergistic malignant potential.

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Identification of a novel non-immunoglobulin/MYC translocation t(8;12)(q24;p12) involving the LRMP gene in a primary B-cell lymphoma. A case report

Cited by 3 publications

References 7 publications

Sequence based analysis of U-2973, a cell line established from a double-hit B-cell lymphoma with concurrent MYC and BCL2 rearrangements

Sequence based analysis of U-2973, a cell line established from a double-hit B-cell lymphoma with concurrent MYC and BCL2 rearrangements

t(3;12)(q27;p12) LRMP/BCL6

Current Perspectives in Genetics of “Double-Hit” Lymphoma with Possible Clinical Implications

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