2022
DOI: 10.1002/cam4.5384
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Identification of a novel prognostic signature correlated with epithelial‐mesenchymal transition, N6‐methyladenosine modification, and immune infiltration in colorectal cancer

Abstract: Objective: Colorectal cancer (CRC) is a commonly diagnosed human malignancy worldwide. Both epithelial-mesenchymal transition (EMT) and N6methyladenosine (m6A) modification play a crucial role in CRC development.This study aimed to construct a prognostic signature based on the genes related to EMT and m6A modification.Method: Firstly, the mRNA expression profiling of CRC tissues was analyzed using TCGA and GEO databases. The prognostic hub genes related to EMT and m6A modification were selected using weighted … Show more

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Cited by 6 publications
(3 citation statements)
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“…TGFβ has been shown previously to upregulate HSF1 in human breast cancer via induction of FAM3C protein 44 . In turn, FAM3C is upregulated under inflammatory conditions such as alveolar echinococcosis 45 Within the colon, FAM3C has been linked to Treg infiltration and increased risk of colorectal cancer 46 . As such, FAM3C may have a role in mediating TGFβ-induced regulation of HSF1 in Tregs in this study.…”
Section: Discussionmentioning
confidence: 99%
“…TGFβ has been shown previously to upregulate HSF1 in human breast cancer via induction of FAM3C protein 44 . In turn, FAM3C is upregulated under inflammatory conditions such as alveolar echinococcosis 45 Within the colon, FAM3C has been linked to Treg infiltration and increased risk of colorectal cancer 46 . As such, FAM3C may have a role in mediating TGFβ-induced regulation of HSF1 in Tregs in this study.…”
Section: Discussionmentioning
confidence: 99%
“…For example, JARID2 is overexpressed in hepatocellular carcinoma (HCC) tissues [ 7 ], where its upregulation promotes EMT by inhibiting the phosphatase and tension homolog (PTEN)-induced AKT hyperactivation, resulting in enhanced invasion of HCC cells. Knockdown of JARID2 inhibits transforming growth factor-beta (TGF-β)-induced EMT in colon cancer HT29 cells and lung cancer A549 cells [ 10 , 13 ]. Knockdown of JARID2 has been reported to impair the invasive and tumorigenic abilities of bladder cancer cells, reducing the number of tumor-initiating cells, suggesting an important role of JARID2 in the progression of OSCC [ 18 ].…”
Section: Discussionmentioning
confidence: 99%
“…Studies have found that m6A modi cation plays an important role in tumor proliferation, differentiation, invasion, and metastasis, and M6A regulates many aspects of the development of colorectal cancer (CRC) [30,31]. Therefore, it is of great signi cance to study the regulation of m6A in colorectal cancer, to identify new therapeutic targets and potential therapeutic drugs, and to improve the prognosis of CRC patients.…”
Section: Discussionmentioning
confidence: 99%