2002
DOI: 10.1038/sj.onc.1205877
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Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability

Abstract: cDNA microarray hybridization was used in an attempt to identify novel genes participating in cellular responses to prolonged hypoxia. One of the identified novel genes, designated Hi95 shared significant homology to a p53-regulated GADD family member PA26. In addition to its induction in response to prolonged hypoxia, the increased Hi95 transcription was observed following DNA damage or oxidative stress, but not following hyperthermia or serum starvation. Whereas induction of Hi95 by prolonged hypoxia or by o… Show more

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Cited by 330 publications
(401 citation statements)
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“…The induction by hypoxia treatment is p53 independent while the induction by oxidative stress and DNA damage is p53 dependent and modulated by serum levels as seen for PA26 (Budanov et al, 2002). Moreover, the overexpression of Hi95 protects cells from hydrogen peroxide treatment.…”
Section: Discovery and Initial Characterization Of Sestrinmentioning
confidence: 87%
“…The induction by hypoxia treatment is p53 independent while the induction by oxidative stress and DNA damage is p53 dependent and modulated by serum levels as seen for PA26 (Budanov et al, 2002). Moreover, the overexpression of Hi95 protects cells from hydrogen peroxide treatment.…”
Section: Discovery and Initial Characterization Of Sestrinmentioning
confidence: 87%
“…Previous studies have shown that Sesn2 expression inhibits cell growth and proliferation in response to a genotoxic stress. 15,36 However, in the same study, the expression of Sesn2 protected MCF-7 cells against ischemia/low glucose and H 2 O 2 . These results reveal that Sesn2 has a different role depending on the nature of the stress, and our study demonstrates that Sesn2 counteracts the deleterious effects of the inhibition of glycolysis by 2-DG.…”
Section: Discussionmentioning
confidence: 99%
“…The clamps were then removed, and the incisions were closed. Rats were euthanized at 0, 3,6,12,24,48, and 72 h after surgery (n Ï­ 5 rats/group). The left kidney was rapidly removed and processed for histological evaluation, protein extraction, and RNA extraction, as previously described (38,40).…”
Section: Induction Of Akimentioning
confidence: 99%