2015
DOI: 10.4049/jimmunol.1402026
|View full text |Cite
|
Sign up to set email alerts
|

Identification of a Nuclear Export Sequence in the MHC CIITA

Abstract: Initiation of an immune response through expression of MHC class II and related genes is under the control of the CIITA. Normally found in both the cytoplasm and nucleus, CIITA is tightly controlled by a variety of posttranslational modifications as well as interactions with other nuclear and cytoplasmic factors, whereas disruption of this dual subcellular localization impairs CIITA functioning and expression of target genes. Although CIITA has well-defined domains necessary for its nuclear import, the region … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
10
0

Year Published

2016
2016
2023
2023

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 11 publications
(10 citation statements)
references
References 64 publications
0
10
0
Order By: Relevance
“…Immunohistological analysis verified that the small complement of b-cells expressing Class II also stain for CIITA, which was mainly located in the cytoplasm rather than in the nucleus. Nuclear CIITA has been visualized using green fluorescent protein or FLAGtagged CIITA (35,36), or by using sufficient nuclear protein for Western blot detection. However, we were unable to detect CIITA protein in the nucleus of endocrine or immune cells in pancreas tissue sections, in human tonsillar tissue sections ( Supplementary Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Immunohistological analysis verified that the small complement of b-cells expressing Class II also stain for CIITA, which was mainly located in the cytoplasm rather than in the nucleus. Nuclear CIITA has been visualized using green fluorescent protein or FLAGtagged CIITA (35,36), or by using sufficient nuclear protein for Western blot detection. However, we were unable to detect CIITA protein in the nucleus of endocrine or immune cells in pancreas tissue sections, in human tonsillar tissue sections ( Supplementary Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Several proteins known to play a major role in cHL oncogenesis, including STAT1/STAT6, FOXO1 or CIITA are also identified as cargo proteins. [34][35][36] Whether the XPO1 mutations may interfere with the nucleus/cytoplasm shuttle of these proteins remains to be determined.…”
Section: P=0000366 Diagnosis > Eotmentioning
confidence: 99%
“…The specificity of leptomycin B has been used to validate the CRM1-dependent export of many NES- containing proteins including actin [ 181 ], cytokines [ 140 ], tyrosine kinases [ 169 ], cyclin-CDK [ 75 , 191 ], MDM2/p53 [ 64 ], inhibitors of NF-κB transcription [ 155 ] and MHC class II complexes [ 36 ]. Inhibition by this drug results in the accumulation of these key regulatory proteins which eventually leads to cell death.…”
Section: Targeting Nucleo-cytoplasmic Transport: Leptomycin Bmentioning
confidence: 99%