Identification of a Proliferation Signature Related to Survival in Nodal Peripheral T-Cell Lymphomas

Abstract

Our findings indicate that proliferation could be an important factor in evaluating nodal PTCL outcome and may help to define a more aggressive phenotype.

New molecular insights into peripheral T cell lymphomas

“…Two years later, our group refined this scoring system by substituting Ki67 expression for bone marrow involvement (3), which allowed for the identification of three distinct subgroups of patients with clearly different clinical behavior. Remarkably, the proposed score considered for the first time a biological parameter (the proliferative index), consistent with the observation made later by Cuadros et al that a gene signature related to proliferation heralds a poor prognosis (70). Interestingly, we also found in a univariate analysis that EBV positivity and cytotoxic marker expression were adverse prognostic indicators (3).…”

C-MYC is related to GATA3 expression and associated with poor prognosis in nodal peripheral T-cell lymphomas

“…Moreover, C-MYC overexpression is known to be related to a high proliferation index and poor clinical outcome in ALCL. 9 Cuadros et al 10 identified a poor prognosis signature related to proliferation using gene expression studies. Went et al…”

Aspects moléculaires des lymphomes T périphériques (1)

“…Certains profils semblent corrélés à la survie des patients : la surexpression de la voie NFB est associée à un bon pronostic [38], contrairement à la surexpression d'une signature de prolifération qui, elle, est de mauvais pronostic [39]. On distingue plusieurs sous-entités de LTP-NS.…”