Identification of a retinoic acid-inducible endogenous retroviral transcript in the human teratocarcinoma-derived cell line PA-1

Kannan, Perry; Buettner, Reinhard; Pratt, David R.; Tainsky, Michael A.

doi:10.1128/jvi.65.11.6343-6348.1991

Cited by 35 publications

(17 citation statements)

References 43 publications

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“…The inhibitory effect of AtRA on the expression of the E7 oncogene was due to suppression of the HPV16 promoter (p97) (Faluhelyi et al, 2004). In the present study, AtRA treatment significantly increased transcription of both Sp1 and L1 genes, which is similar to a previous report that AtRA activates transcription of an endogenous retrovirus‐related element in the human teratocarcinoma‐derived cell line PA‐1 (Kannan et al, 1991). Conversely, AtRA blocked the translation of Sp1 and L1 proteins, revealing that AtRA differentially regulates transcription and translation of both Sp1 and L1 genes in the primary KC cultures.…”

Section: Discussionsupporting

confidence: 92%

Up-regulated expression of Sp1 protein coincident with a viral protein in human and mouse differentiating keratinocytes may act as a cell differentiation marker

Wang

Zhou

et al. 2008

Differentiation

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Section: Discussionsupporting

confidence: 92%

Up-regulated expression of Sp1 protein coincident with a viral protein in human and mouse differentiating keratinocytes may act as a cell differentiation marker

Wang

Zhou

et al. 2008

Differentiation

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“…Thus, enhanced expression of ERV-3 appears to be related to higher cellular differentiation as observed in a human monoblast cell line exposed to retinoic acid or vitamin D3 [92]. Kannan et al [93] found that retinoic acid could cause the activation of a transcript of another HERV, RRHERV-I, in the human teratocarcinoma-derived cell line PA-1.…”

Section: Vitaminsmentioning

confidence: 94%

Molecular mechanisms mediated by human endogenous retroviruses (HERVs) in autoimmunity

Balada

Ordi‐Ros

Vilardell‐Tarrés

2009

Reviews in Medical Virology

108

105

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Eight per cent of the human genome is derived from the integration of retroviral sequences that were incorporated in our DNA more than 25 million years ago. Although some of these elements show mutations and deletions, some HERVs are transcriptionally active and produce functional proteins. Different mechanisms have been described which link HERVs to some chronic diseases such as several cancers, nervous system diseases and autoimmune rheumatic and connective tissue diseases. They could cause disease because of their capacity for being moved and inserted next to certain genes whose expression would be consequentially altered. Another way in which disease could potentially arise is when HERV-encoded proteins are expressed. These proteins would be considered as [foreign] and they could trigger B-cells to produce antibodies against them, which, in turn, might cross-react with other proteins of our bodies. This mechanism could give rise to autoimmune diseases such as rheumatoid arthritis (RA), lupus erythematosus, Sjögren's syndrome (SJS), mixed connective tissue diseases and inflammatory neurological disease. Furthermore, it should be pointed out that HERV-proteins may act as superantigens. Interestingly, some environmental agents seem to induce the expression of HERVs. Thus, ultraviolet light and several chemical agents could reactivate such sequences by altering their structure without modifying their nucleotide composition when the methylation pattern is changed. Therefore, the epigenetic changes observed in pathological conditions such as systemic lupus erythematosus (SLE) or cancer could be translated into an effect on the activation of some of the retroelements present in our genome which ultimately could have a direct or indirect role on the initiation and clinical evolution of certain chronic diseases.

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“…Of the positive SLE patients, eight had antibody to the Sn nucleoprotein. These authors reported (180) that the proline-rich epitope shared by Sn and p24 of HIV-1 represented 88 URNOVITZ AND MURPHY CLIN. MICROBIOL.…”

Section: Hervs and Autoimmune Diseasementioning

confidence: 99%

Human endogenous retroviruses: nature, occurrence, and clinical implications in human disease

Urnovitz¹,

Murphy²

1996

Clin Microbiol Rev

175

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Retroviral diagnostics have become standard in human laboratory medicine. While current emphasis is placed on the human exogenous viruses (human immunodeficiency virus and human T-cell leukemia virus), evidence implicating human endogenous retroviruses (HERVs) in various human disease entities continues to mount. Literature on the occurrence of HERVs in human tissues and cells was analyzed. Substantial evidence documents that retrovirus particles were clearly demonstrable in various tissues and cells in both health and disease and were abundant in the placenta and that their occurrence could be implicated in some of the reproductive diseases. The characteristics of HERVs are summarized, mechanisms of replication and regulation are outlined, and the consistent hormonal responsiveness of HERVs is noted. Clear evidence implicating HERV gene products as participants in glomerulonephritis in some cases of systemic lupus erythematosus is adduced. Data implicating HERVs as etiologic factors in reproductive diseases, in some of the autoimmune diseases, in some forms of rheumatoid arthritis and connective tissue disease, in psoriasis, and in some of the inflammatory neurologic diseases are reviewed. The current major needs are to improve methods for HERV detection, to identify the most appropriate HERV prototypes, and to develop diagnostic reagents so that the putative biologic and pathologic roles of HERVs can be better evaluated.

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Identification of a retinoic acid-inducible endogenous retroviral transcript in the human teratocarcinoma-derived cell line PA-1

Cited by 35 publications

References 43 publications

Up-regulated expression of Sp1 protein coincident with a viral protein in human and mouse differentiating keratinocytes may act as a cell differentiation marker

Up-regulated expression of Sp1 protein coincident with a viral protein in human and mouse differentiating keratinocytes may act as a cell differentiation marker

Molecular mechanisms mediated by human endogenous retroviruses (HERVs) in autoimmunity

Human endogenous retroviruses: nature, occurrence, and clinical implications in human disease

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