Identification of a Third Human Polyomavirus

Allander, Tobias; Andreasson, Kalle; Gupta, Shawon; Bjerkner, Annelie; Bogdanović, Gordana; Persson, Mats A. A.; Dalianis, Tina; Ramqvist, Torbjörn; Andersson, Björn

doi:10.1128/jvi.00028-07

Cited by 570 publications

(557 citation statements)

References 34 publications

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“…The novel polyomavirus KIV was first described by Allander et al [2007] in the respiratory secretions of children with acute respiratory symptoms and later confirmed by other groups around the world [Bialasiewicz et al, 2007;Babakir-Mina et al, 2008]. Whether this reflects a causal role of the virus in the respiratory illness is still debated and molecular epidemiological studies are needed to establish a firm link with the respiratory disease.…”

Section: Discussionmentioning

confidence: 99%

“…The KIV was detected amplifying a fragment of the VP1 gene as described [Allander et al, 2007]. The positive cases were then amplified for the early region of KIV genome comprising the C-terminal part of T-Ag gene and the almost entire t-Ag gene [Allander et al, 2007].…”

Section: Amplification Of the Vp1 Gene And Early Region Of Kiv Genomementioning

confidence: 99%

“…The positive cases were then amplified for the early region of KIV genome comprising the C-terminal part of T-Ag gene and the almost entire t-Ag gene [Allander et al, 2007]. The PCR primers were as follows: FT-Ag 5 0 -CCACA-CAGGTGGTTTTCTATAA-3 0 (position 4521-4542) and RT-Ag 5 0 -GCCCCAGCTTTTTCTAGAAGAA-3 0 (position 5032-5011).…”

Section: Amplification Of the Vp1 Gene And Early Region Of Kiv Genomementioning

confidence: 99%

“…Recently, a new human polyomavirus, KI polyomavirus (KIV) has been identified in the respiratory secretions of children with acute respiratory symptoms [Allander et al, 2007]. Debated is its causal role in the respiratory disease [Bialasiewicz et al, 2007;Norja et al, 2007;Babakir-Mina et al, 2008] as completely unknown is its oncogenic potential.…”

Section: Introductionmentioning

confidence: 99%

“…Debated is its causal role in the respiratory disease [Bialasiewicz et al, 2007;Norja et al, 2007;Babakir-Mina et al, 2008] as completely unknown is its oncogenic potential. The objective of the study was to determine the presence of KIV in normal and malignant lung tissue as well as in a normal paranasal tissue and to compare the early region of KIV genome, comprising the C-terminal region of the T-Ag gene and almost the entire t-Ag gene [Allander et al, 2007] with those of known KIV, JCV, and BKV strains.…”

Section: Introductionmentioning

confidence: 99%

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Identification of the novel KI Polyomavirus in paranasal and lung tissues

Babakir‐Mina¹,

Ciccozzi

Campitelli

et al. 2009

Journal of Medical Virology

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KI is a novel polyomavirus identified in the respiratory secretions of children with acute respiratory symptoms. Whether this reflects a causal role of the virus in the human respiratory disease remains to be established. To investigate the presence of KIV in the respiratory tissue, we examined 20 fresh lung cancer specimens and surrounding normal tissue along with one paranasal and one lung biopsy from two transplanted children. KIV‐VP1 gene was detected in 9/20 lung cancer patients and 2/2 transplanted patients. However, amplification of the sequence coding for the C‐terminal part of the early region of KIV performed on the 11 positive cases was successful only in two malignant lung tissues, one surrounding normal tissue, and 1/2 biopsies tested. Phylogenetic analysis performed on the early region of KIV (including the four Italian isolates), BKV and JCV revealed the presence of three distinct clades. Within the KIV clade two sub‐clades were observed. A sub‐clade A containing the four Italian strains, and a sub‐clade B comprising the Swedish and Australian isolates. Interestingly, the two Italian strains identified in normal tissue clustered together, whereas those detected in malignant tissue fell outside this cluster. In vitro studies are needed to investigate the transforming potential of KIV strains. J. Med. Virol. 81:558–561, 2009. © 2009 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Amplification Of the Vp1 Gene And Early Region Of Kiv Genomementioning

confidence: 99%

Section: Amplification Of the Vp1 Gene And Early Region Of Kiv Genomementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Identification of the novel KI Polyomavirus in paranasal and lung tissues

Babakir‐Mina¹,

Ciccozzi

Campitelli

et al. 2009

Journal of Medical Virology

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Specific Detection of Trichodysplasia Spinulosa–Associated Polyomavirus DNA in Skin and Renal Allograft Tissues in a Patient With Trichodysplasia Spinulosa

et al. 2012

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Background: Trichodysplasia spinulosa (TS) is a rare, disfiguring skin condition that affects immunosuppressed patients, universally involving the central face. New data point to the recently discovered TS-associated polyomavirus (TSPyV) as the causative agent. Observations:We report a case of TS in a 48-year-old African American man after renal transplant; via polymerase chain reaction and sequencing, confirm the detection of TSPyV in lesional skin; and report the novel detection of TSPyV DNA in renal allograft tissue. Results of polymerase chain reaction analysis were negative for Merkel cell polyomavirus in lesional skin. Fifteen months later, urine cytologic findings showed morphologic evidence of a urinary tract polyomavirus infection. Results of SV40 immunohistochemical analysis were negative in lesional skin, renal allograft, and urine specimens. Conclusions:To our knowledge, this is the first reported case in which TSPyV DNA has been detected in extracutaneous tissues and the third with combined ultrastructural and molecular confirmation of the presence of TSPyV in lesional skin. Lack of detection of other pathogenic human polyomaviruses in this patient's skin supports the specific role of this polyomavirus in the genesis of TS. Further basic science studies are needed to determine the exact pathomechanisms of this polyomavirus and to explore possible tumorigenic roles in other skin diseases.

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Natalizumab and Progressive Multifocal Leukoencephalopathy

Warnke¹,

Menge²,

Hartung³

et al. 2010

Arch Neurol

107

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atalizumab (Tysabri) was the first monoclonal antibody approved for the treatment of relapsing forms of multiple sclerosis (MS). After its initial approval, 3 patients undergoing natalizumab therapy in combination with other immunoregulatory and immunosuppressive agents were diagnosed with progressive multifocal leukoencephalopathy (PML). The agent was later reapproved and its use restricted to monotherapy in patients with relapsing forms of MS. Since reapproval in 2006, additional cases of PML were reported in patients with MS receiving natalizumab monotherapy. Thus, there is currently no convincing evidence that natalizumab-associated PML is restricted to combination therapy with other diseasemodifying or immunosuppressive agents. In addition, recent data indicate that risk of PML might increase beyond 24 months of treatment.

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Identification of a Third Human Polyomavirus

Cited by 570 publications

References 34 publications

Identification of the novel KI Polyomavirus in paranasal and lung tissues

Identification of the novel KI Polyomavirus in paranasal and lung tissues

Specific Detection of Trichodysplasia Spinulosa–Associated Polyomavirus DNA in Skin and Renal Allograft Tissues in a Patient With Trichodysplasia Spinulosa

Natalizumab and Progressive Multifocal Leukoencephalopathy

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