1997
DOI: 10.1006/bbrc.1997.6588
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Identification of a Unique Monocarboxylate Transporter (MCT3) in Retinal Pigment Epithelium

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Cited by 136 publications
(101 citation statements)
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“…4). Our observation is similar to what has been described in RPE in situ (6,10,14,25,26). Furthermore, the human RPE cell line ARPE-19 expresses CD147 and MCT1 at the apical membrane and MCT4 and CD147 at the basolateral membrane (ref.…”
Section: Mechanisms Underlying Mct Polarity In Rpesupporting
confidence: 90%
See 1 more Smart Citation
“…4). Our observation is similar to what has been described in RPE in situ (6,10,14,25,26). Furthermore, the human RPE cell line ARPE-19 expresses CD147 and MCT1 at the apical membrane and MCT4 and CD147 at the basolateral membrane (ref.…”
Section: Mechanisms Underlying Mct Polarity In Rpesupporting
confidence: 90%
“…Monocarboxylate transporters (MCTs) are nonglycosylated multispan proteins with 12 predicted transmembrane domains and cytoplasmic N-and C-terminal ends (6,(10)(11)(12)(13)(14). Of 14 known family members, only MCT1-MCT4 are well characterized; they share 40-60% homology and have distinct tissue distribution and lactate͞ proton transport kinetics (15,16).…”
mentioning
confidence: 99%
“…This is significantly greater than the 43 % and 45 % sequence identity that it shares with MCT1 and MCT2 respectively [16]. However, this degree of identity is lower than might be expected between species.…”
Section: Sequence Analysis Of New Mctsmentioning
confidence: 70%
“…A cDNA has been identified in a chicken retinal cDNA library that encodes a developmentally regulated integral membrane protein of 50 kDa that seems to be closely related to MCT1 and MCT2. The protein was shown to be expressed in chick retinal epithelia and was initially named REMP (retinal epithelial membrane protein) [15] and subsequently functionally expressed and renamed MCT3 [16]. Hydrophobicity plots again predict 12 TM domains similar to MCT1 and MCT2, with which it shares 43 % and 45 % identity respectively [16].…”
Section: Introductionmentioning
confidence: 99%
“…Their expression in the CNS appears to be preferentially associated with (but not always restricted to) a particular cell type, often correlating with their main metabolic phenotype. Thus, MCT1, MCT2, and MCT4 are predominantly expressed, respectively, in oligodendrocytes, neurons, and astrocytes (Lee et al, 2012), while MCT3 is found only in retinal pigment epithelial cells (Yoon et al, 1997).…”
Section: Introductionmentioning
confidence: 99%