Identification of A2a Adenosine Receptor Domains Involved in Selective Coupling to GS

Olah, Mark E.

doi:10.1074/jbc.272.1.337

Cited by 77 publications

(42 citation statements)

References 49 publications

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“…Interestingly, A 2a and A 2b are both coupled to G s protein and cause an increase in adenylyl cyclase activity (31,33), in contrast to A 1 and A 3 adenosine receptors. A 2a is effective in curbing LPS-mediated lung inflammation via activation of A 2a receptor on hematopoietic cells (37).…”

Section: Discussionmentioning

confidence: 99%

Adenosine receptor A_2b on hematopoietic cells mediates LPS-induced migration of PMNs into the lung interstitium

Konrad

Witte

Vollmer

et al. 2012

American Journal of Physiology-Lung Cellular and Molecular Phys

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Section: Discussionmentioning

confidence: 99%

Adenosine receptor A_2b on hematopoietic cells mediates LPS-induced migration of PMNs into the lung interstitium

Konrad

Witte

Vollmer

et al. 2012

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…Activation of both A 2A and A 2B has been shown to increase intracellular cAMP levels in many different cell types, including mast cells (Pierce et al, 1992;Feoktistov and Biaggioni, 1995;Olah, 1997;Fredholm et al, 2000). However, whether activation of G s -coupled adenosine receptors in mast cells inhibits mast cell activation is still controversial, especially in vivo.…”

Section: Introductionmentioning

confidence: 99%

G_s-Coupled Adenosine Receptors Differentially Limit Antigen-Induced Mast Cell Activation

Hua

Chason

Jania

et al. 2012

J Pharmacol Exp Ther

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Mast cell activation results in the immediate release of proinflammatory mediators prestored in cytoplasmic granules, as well as initiation of lipid mediator production and cytokine synthesis by these resident tissue leukocytes. Allergen-induced mast cell activation is central to the pathogenesis of asthma and other allergic diseases. Presently, most pharmacological agents for the treatment of allergic disease target receptors for inflammatory mediators. Many of these mediators, such as histamine, are released by mast cells. Targeting pathways that limit antigen-induced mast cell activation may have greater therapeutic efficacy by inhibiting the synthesis and release of many proinflammatory mediators produced in the mast cell. In vitro studies using cultured human and mouse mast cells, and studies of mice lacking A 2B receptors, suggest that adenosine receptors, specifically the G s -coupled A 2A and A 2B receptors, might provide such a target. Here, using a panel of mice lacking various combinations of adenosine receptors, and mast cells derived from these animals, we show that adenosine receptor agonists provide an effective means of inhibition of mast cell degranulation and induction of cytokine production both in vitro and in vivo. We identify A 2B as the primary receptor limiting mast cell degranulation, whereas the combined activity of A 2A and A 2B is required for the inhibition of cytokine synthesis.

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“…In PD and dyskinesia, attention has been drawn to A 2A receptors, which will be the primary focus of this section. A 2A receptors are primarily coupled to a Gs protein (Olah, 1997). A 2A receptors are located on striatal neurons forming the indirect pathway (Morelli et al, 2007;Schiffmann et al, 2007) and can form heterodimers with both D 2 (Canals et al, 2003) and mGlu5 (Ferre et al, 2002) receptors.…”

Section: The Adenosine Systemmentioning

confidence: 99%

The Pharmacology of l-DOPA-Induced Dyskinesia in Parkinson’s Disease

Huot

Johnston²,

Koprich³

et al. 2013

Pharmacol Rev

294

230

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Identification of A2a Adenosine Receptor Domains Involved in Selective Coupling to GS

Cited by 77 publications

References 49 publications

Adenosine receptor A_2b on hematopoietic cells mediates LPS-induced migration of PMNs into the lung interstitium

Adenosine receptor A_2b on hematopoietic cells mediates LPS-induced migration of PMNs into the lung interstitium

G_s-Coupled Adenosine Receptors Differentially Limit Antigen-Induced Mast Cell Activation

The Pharmacology of l-DOPA-Induced Dyskinesia in Parkinson’s Disease

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Identification of A2a Adenosine Receptor Domains Involved in Selective Coupling to GS

Cited by 77 publications

References 49 publications

Adenosine receptor A2b on hematopoietic cells mediates LPS-induced migration of PMNs into the lung interstitium

Adenosine receptor A2b on hematopoietic cells mediates LPS-induced migration of PMNs into the lung interstitium

Gs-Coupled Adenosine Receptors Differentially Limit Antigen-Induced Mast Cell Activation

The Pharmacology of l-DOPA-Induced Dyskinesia in Parkinson’s Disease

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Adenosine receptor A_2b on hematopoietic cells mediates LPS-induced migration of PMNs into the lung interstitium

Adenosine receptor A_2b on hematopoietic cells mediates LPS-induced migration of PMNs into the lung interstitium

G_s-Coupled Adenosine Receptors Differentially Limit Antigen-Induced Mast Cell Activation