The application of centrifugal compressors is extensive in industries such as aerospace and energy. The blade is the primary factor affecting the aerodynamic performance of compressors. In this paper, the aerodynamic performance of a centrifugal compressor with leaned and bowed 3D blades is investigated. The spanwise section profiles of the blade in the circumferential direction are deflected at different angles, resulting in four compressors with distinct leaned and bowed 3D blades based on the original model. There is a significant change in isentropic efficiency of the modified models under design conditions. Specifically, models 1, 3, and 4 experienced an increase of 0.97%, 1.04%, and 0.79%, respectively, while model 2 experienced a decrease of 0.70%. The profile of the blade tip and 50% spanwise section are shifted towards the suction surface, resulting in a geometric structure where the blade is concave towards the pressure surface. This structure gradually lifts the flow from the blade root to the blade tip downstream to the outlet area of the flow channel, reducing the load on the trailing edge of the blade and making the flow more closely aligned with the blade. At the same time, the larger radial velocity gradient near the blade tip suppresses the backflow on the shroud side, making the flow at the impeller outlet more stable. The outlet velocity of the impeller is more evenly distributed along the spanwise and circumferential directions, which improves the flow at the inlet of the diffuser and enhances the efficiency of the diffuser. Due to the high spanwise height of the leading edge of the blade, this bowed blade structure has little effect on the spanwise curvature upstream of the blade, resulting in negligible influence on the flow of the upstream channel.