Identification of allosteric hotspots regulating the ribosomal RNA binding by antibiotic resistance-conferring Erm methyltransferases

Bhujbalrao, R.; Gavvala, Krishna; Singh, Reman Kumar; Singh, Juhi; Boudier, Christian; Chakrabarti, Sutapa; Patwari, G. Naresh; Anand, Ruchi

doi:10.1016/j.jbc.2022.102208

Cited by 5 publications

(2 citation statements)

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“…found that the absence of a single methylation in 23S rRNA affected 50S assembly and impaired translation initiation and elongation ( Wang et al., 2020 ). In addition, rRNA methylation has emerged as a significant mechanism of AMR in pathogenic bacterial infections, such as aminoglycoside and macrolide resistance ( Bhujbalrao et al., 2022 ; Srinivas et al., 2023 ).…”

Section: What Is Epigenetics?mentioning

confidence: 99%

“…In S. pneumoniae , U747 methylation mediated by RlmCD promotes efficient G748 methylation by the MTase RlmA II in 23S rRNA, affecting the susceptibility to telithromycin ( Shoji et al., 2015 ). Another research indicated the erythromycin-resistance MTase methylates rRNA at the conserved A2058 position, and imparts resistance to macrolides, such as erythromycin ( Bhujbalrao et al., 2022 ). Up to now, the number of rRNA MTases related to AMR mechanisms have increased, but the source of MTases and the exact mechanisms of AMR are still unclear.…”

Section: Bacterial Epigenetics Mediating Antibiotic Resistancementioning

confidence: 99%

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Antimicrobial resistance and mechanisms of epigenetic regulation

Wang

2023

Front. Cell. Infect. Microbiol.

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The rampant use of antibiotics in animal husbandry, farming and clinical disease treatment has led to a significant issue with pathogen resistance worldwide over the past decades. The classical mechanisms of resistance typically investigate antimicrobial resistance resulting from natural resistance, mutation, gene transfer and other processes. However, the emergence and development of bacterial resistance cannot be fully explained from a genetic and biochemical standpoint. Evolution necessitates phenotypic variation, selection, and inheritance. There are indications that epigenetic modifications also play a role in antimicrobial resistance. This review will specifically focus on the effects of DNA modification, histone modification, rRNA methylation and the regulation of non-coding RNAs expression on antimicrobial resistance. In particular, we highlight critical work that how DNA methyltransferases and non-coding RNAs act as transcriptional regulators that allow bacteria to rapidly adapt to environmental changes and control their gene expressions to resist antibiotic stress. Additionally, it will delve into how Nucleolar-associated proteins in bacteria perform histone functions akin to eukaryotes. Epigenetics, a non-classical regulatory mechanism of bacterial resistance, may offer new avenues for antibiotic target selection and the development of novel antibiotics.

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Section: What Is Epigenetics?mentioning

confidence: 99%

Section: Bacterial Epigenetics Mediating Antibiotic Resistancementioning

confidence: 99%