2016
DOI: 10.1155/2016/1679574
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Identification of Alternative Variants and Insertion of the Novel PolymorphicAluYl17inTSEN54Gene during Primate Evolution

Abstract: TSEN54 encodes a subunit of the tRNA-splicing endonuclease complex, which catalyzes the identification and cleavage of introns from precursor tRNAs. Previously, we identified an AluSx-derived alternative transcript in TSEN54 of cynomolgus monkey. Reverse transcription-polymerase chain reaction (RT-PCR) amplification and TSEN54 sequence analysis of primate and human samples identified five novel alternative transcripts, including the AluSx exonized transcript. Additionally, we performed comparative expression a… Show more

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Cited by 7 publications
(5 citation statements)
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“…Alu elements emerged 65 million years ago before the radiation of primates by a fusion of 5′ and 3′ ends of the 7 SL RNA gene [34]. Alu elements have been continuously inserted into host genomes, which has been contributed to an increase in transcriptome diversity and resulted in positive effects on primate evolution [35][36][37][38]. However, insertion of individual Alu elements can also negatively impact genome stability through the induction of gene mutation, potentially leading to genetic diseases and cancer [13,36,39,40].…”
Section: Discussionmentioning
confidence: 99%
“…Alu elements emerged 65 million years ago before the radiation of primates by a fusion of 5′ and 3′ ends of the 7 SL RNA gene [34]. Alu elements have been continuously inserted into host genomes, which has been contributed to an increase in transcriptome diversity and resulted in positive effects on primate evolution [35][36][37][38]. However, insertion of individual Alu elements can also negatively impact genome stability through the induction of gene mutation, potentially leading to genetic diseases and cancer [13,36,39,40].…”
Section: Discussionmentioning
confidence: 99%
“…TEs have moved around the genome over the past hundreds of million years and shaped the evolution of the human and non-human primate genomes [25, 26]. Previous studies have indicated that TE insertions are associated with more than 100 diseases to date because of their association with increasing genomic instability [27, 28].…”
Section: Discussionmentioning
confidence: 99%
“…tRNA Splicing Endonuclease Subunit 54 (TSEN54) is located on 17q25.1 of the human genome and encodes a protein constituting a subunit of the tRNA splicing endonuclease heterotetramer [9]. TSEN54 is a noncatalytic subunit responsible for recognizing the precursor tRNA substrate and for localizing the two catalytic subunits TSEN2 and TSEN34 localize to the 5' -splice site and 3' -splice site respectively, thereby splicing the pre-tRNA release intron [10].…”
Section: Introductionmentioning
confidence: 99%