Identification of an AII(3–8) [AIV] binding site in guinea pig hippocampus

Harding, Joseph W.; Cook, Victoria I.; Miller-Wing, Allison V.; Hanesworth, Jodie M.; Sardinia, Michael F.; Hall, K.; Stobb, Jeff W.; Swanson, Geoff N.; Coleman, John K.M.; Wright, John W.; Harding, Erin C.

doi:10.1016/s0006-8993(10)80047-2

Cited by 147 publications

(76 citation statements)

References 14 publications

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“…Of most importance, the acute application of one of these analogs, Nle 1 -AngIV, reverses deficits in dementia models induced by 1) treatment with the cholinergic muscarinic receptor antagonist scopolamine (Pederson et al, 2001), 2) kainic acid injections into the hippocampus (Stubley-Weatherly et al, 1996), 3) perforant path cuts (Wright et al, 1999), and 4) ischemia resulting from transient four-vessel occlusion . Consistent with these behavioral and electrophysiological results, brain binding sites for 125 I-AngIV have been autoradiographically localized in structures known to mediate cognitive processing including the neocortex, hippocampus, and basal nucleus of Meynert (Harding et al, 1992;Chai et al, 2000;Wright and Harding, 2008). It should be noted that the AT 1 angiotensin receptor subtype may also contribute to the cognitive effects of AngIV (De Bundel et al, 2010).…”

Section: Introductionsupporting

confidence: 65%

Facilitation of Hippocampal Synaptogenesis and Spatial Memory by C-Terminal Truncated Nle¹-Angiotensin IV Analogs

Benoist

Wright²,

Zhu³

et al. 2011

J Pharmacol Exp Ther

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Section: Introductionsupporting

confidence: 65%

Facilitation of Hippocampal Synaptogenesis and Spatial Memory by C-Terminal Truncated Nle¹-Angiotensin IV Analogs

Benoist

Wright²,

Zhu³

et al. 2011

J Pharmacol Exp Ther

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“…[8][9][10][11][12] The distribution between species is consistent with high levels of radioligand binding observed in the motor nuclei and in areas associated with cognitive and sensorimotor functions, such as the hippocampus, neocortex and cerebellum. Of particular interest is the occurrence of high affinity binding in areas associated with memory; areas of basal forebrain cholinergic nuclei, including the medial septal complex and the basal nucleus of Meynert, and their terminal fields, such as the hippocampus and neocortex.…”

Section: Angiotensin IVsupporting

confidence: 59%

Alzheimer's, Angiotensin IV and an Aminopeptidase

Albiston

Fernando

et al. 2004

Biological & Pharmaceutical Bulletin

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The angiotensin AT 4 receptor was originally defined as the specific, high affinity binding site for the hexapeptide angiotensin IV (Ang IV). Subsequently, the peptide LVV-hemorphin 7 was also demonstrated to be a bioactive ligand of the AT 4 receptor. Central administration of Ang IV or LVV-hemorphin 7 (LVV-H7) markedly enhances learning and memory in normal rodents and reverse memory deficits observed in animal models of amnesia. The high affinity binding site has a broad distribution in the brain including areas such as the hippocmapus that are involved in memory processing. The high affinity Ang IV binding site (AT 4 receptor) has been identified as the transmembrane enzyme, insulin-regulated membrane aminopeptidase (IRAP). Insulin-regulated aminopeptidase is a type II integral membrane spanning protein belonging to the M1 family of aminopeptidases and in insulin-responsive cells colocalizes with GLUT4 in specific intra-cellular vesicles. Both Ang IV and LVV-H7 are competitive inhibitors of IRAP catalytic activity and are not substrates of the enzyme.

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“…56,57 This binding site shows high selectivity for Ang IV followed by Ang III (10-fold lower affinity) ӷ Ang II, [Sar 1 Ile 8 ] Ang II ӷ losartan, PD 123177 and CGP 42112A. [58][59][60][61][62] The AT 4 receptor also displays a distinct distribution pattern, being found in the cholinergic areas and motor and sensory regions in the brain. 59,63 It is also found in the heart, 60 adrenal cortex, 57,64 vascular smooth muscle cells, 61 and numerous other tissues.…”

Section: Ang IVmentioning

confidence: 99%

Bioactive angiotensin peptides

et al. 1998

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Angiotensin II is recognised as the principle active peptide of the renin-angiotensin system, exerting effects on fluid and electrolyte homeostasis, and cardiovascular control including neural and long term trophic effects. However, recent studies indicate that other angiotensin peptides such as angiotensin III, angiotensin II (1-7) and angiotensin IV, may have specific actions. Interestingly, recent work involving angiotensin IV demonstrates that this peptide binds to specific receptors and may be Keywords: angiotensin metabolites; angiotensin III; angiotensin II(1-7); angiotensin IV; globin Bioactive angiotensin peptidesThe renin-angiotensin system (RAS) was initially identified as a circulating humoral system with the effector peptide, angiotensin II (Ang II), generated by an enzymatic cascade. Angiotensinogen, which is synthesized in the liver, is cleaved by renin, a product of the juxtaglomerular cells of the kidney, to form Ang I, which in turn is cleaved by angiotensinconverting enzyme (ACE) to form Ang II. ACE is membrane bound and predominates on the endothelial cells of all vascular beds. Apart from the production of Ang II in plasma, Ang II, renin and ACE have all been described in tissues such as the brain, kidney, adrenal, vasculature, heart and ovaries. This suggests a separate and distinct RAS in these tissues and implies endocrine, paracrine and autocrine roles for Ang II. Actions of Ang IIAng II regulates blood pressure, fluid volume homeostasis and pituitary hormone release via AT 1 and AT 2 receptors located in the kidney, adrenal gland, and the cardiovascular and nervous systems. [2][3][4][5] In the kidney, for instance, Ang II acts on renal vessels, glomeruli, tubules and renomedullary interstitial cells, to alter renal blood flow, glomerular filtration rate and electrolyte reabsorption.6-9 Ang II also acts on the adrenal cortex to stimulate aldosterone secretion and hence renal sodium reabsorption. 10Ang II is a potent vasoconstrictor, acting directly on vascular smooth muscle and indirectly via facilitation of noradrenaline release from sympathetic terminals. 11,12 In the heart, Ang II exerts positive iono- tropic and chronotropic effects and facilitates sympathetic activity. 13Acting on the brain, Ang II induces fluid and salt ingestion, modulates neuroendocrine systems, including vasopressin and corticotropin releasing factor release, and interacts with the autonomic control of the cardiovascular system to influence blood pressure. 3,14,15 In many instances, these effects are complementary to those of the systemic peptide on peripheral target organs. Thus, systematic Ang II affects the brain through AT 1 receptors located in the circumventricular organs, regions with a deficient blood brain barrier. In addition, endogenous neurally derived Ang II appears to act at many central nervous system sites behind the blood brain barrier. [16][17][18] Most of the classical actions of Ang II are mediated via the AT 1 receptor whereas AT 2 receptor stimulation may cause opposing effects. This was o...

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Identification of an AII(3–8) [AIV] binding site in guinea pig hippocampus

Cited by 147 publications

References 14 publications

Facilitation of Hippocampal Synaptogenesis and Spatial Memory by C-Terminal Truncated Nle¹-Angiotensin IV Analogs

Facilitation of Hippocampal Synaptogenesis and Spatial Memory by C-Terminal Truncated Nle¹-Angiotensin IV Analogs

Alzheimer's, Angiotensin IV and an Aminopeptidase

Bioactive angiotensin peptides

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Identification of an AII(3–8) [AIV] binding site in guinea pig hippocampus

Cited by 147 publications

References 14 publications

Facilitation of Hippocampal Synaptogenesis and Spatial Memory by C-Terminal Truncated Nle1-Angiotensin IV Analogs

Facilitation of Hippocampal Synaptogenesis and Spatial Memory by C-Terminal Truncated Nle1-Angiotensin IV Analogs

Alzheimer's, Angiotensin IV and an Aminopeptidase

Bioactive angiotensin peptides

Contact Info

Product

Resources

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Facilitation of Hippocampal Synaptogenesis and Spatial Memory by C-Terminal Truncated Nle¹-Angiotensin IV Analogs

Facilitation of Hippocampal Synaptogenesis and Spatial Memory by C-Terminal Truncated Nle¹-Angiotensin IV Analogs