Identification of an antihypertensive peptide from peptic digest of wakame (Undaria pinnatifida)

Suetsuna, Kunio; Nakano, Takahisa

doi:10.1016/s0955-2863(00)00110-8

Cited by 225 publications

(113 citation statements)

References 23 publications

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“…Due to the specify of Neutrase used in the present study, some hydrophobic amino acids such as leucine and phenylalanine in some peptides might be attached covalently into other peptides by transpeptidation, or some peptides with hydrophobic amino acids were conjugated covalently into other peptides by condensation. All these reactions might lead to these newly formed peptides higher content of hydrophobic amino acids and thus higher ACE-inhibitory activity, as it had been revealed that most naturally occurring ACE-inhibitory peptides are rich in hydrophobic amino acids (Cheung et al 1980;Suetsuna and Nakano 2000). More studies are thus needed to investigate the peptide compositions in the MCH in later work to reveal the most active peptides.…”

Section: Ace-inhibitory Activity In Vitro Of the Modified Casein Hydrmentioning

confidence: 99%

Optimization of some conditions of Neutrase-catalyzed plastein reaction to mediate ACE-inhibitory activity in vitro of casein hydrolysate prepared by Neutrase

Kong

Zhao

2011

J Food Sci Technol

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Casein hydrolysate was prepared by hydrolyzing casein with Neutrase and then modified by a Neutrasecatalyzed plastein reaction. The prepared hydrolysate had a degree of hydrolysis of 13.0% and exhibited ACE inhibition in vitro with an IC 50 value of 40.4 μg⋅mL −1 . With the decreased amount of free amino groups of the modified hydrolysate as the response, some conditions of the plastein reaction including substrate concentration, enzyme to substrate ratio, reaction temperature and time were studied by single factor experiments and response surface methodology, and optimized finally as 62% (w/w), 3.0 kU⋅g −1 peptides, 30°C and 6.3 h, respectively. The maximum decreased amount of free amino groups of the modified hydrolysate prepared under these optimized conditions was 210.0 μmol⋅g −1 peptides, while corresponding IC 50 value was lowered to 14.7 μg⋅mL −1 . The present result indicates that Neutrase-catalyzed plastein reaction was capable of enhancing ACE-inhibitory activity in vitro of casein hydrolysate, and also highlights the importance of a forthcoming study to investigate the peptide compositions of the modified hydrolysate and the role of protease used in the plastein reaction.

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Section: Ace-inhibitory Activity In Vitro Of the Modified Casein Hydrmentioning

confidence: 99%

Optimization of some conditions of Neutrase-catalyzed plastein reaction to mediate ACE-inhibitory activity in vitro of casein hydrolysate prepared by Neutrase

Kong

Zhao

2011

J Food Sci Technol

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“…[29] In addition to peptide size, different amino acid residues and peptide sequences may play an important role in determining ACE-inhibitory activities. Some studies suggested that most naturally occurring ACE-inhibitory peptides contain Pro, Lys, or aromatic amino acid residues.- [30][31][32] Peptides bound to ACE are strongly influenced by the C-terminal sequence, which would be more active with a hydrophobic amino acid at the C-terminal. [33] In the current study, the C-terminal of VQTL is leucine, which is a hydrophobic amino acid.…”

Section: Purification and Identification Of Ace Inhibitory Peptide Ammentioning

confidence: 99%

Purification and identification of angiotensin I-converting enzyme inhibitory peptides from fermented walnut residues

Zheng

Li²,

Ding

2017

International Journal of Food Properties

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Defatted walnut residues (DWR) were hydrolysed using Bacillus subtilis to produce angiotensin-I-converting enzyme (ACE) inhibitory peptides. Fermented walnut residue extract (FWRE) was fractionated using ultrafiltration methods to identify the ACE-inhibitory peptides. The fraction with a molecular weight of <1 kDa (WPs-I) presented the greatest ACE-inhibitory activity. Reverse-phase high-performance liquid chromatography was used to separate WPs-I from the most active fractions, and the amino acid sequence of WPs-I was confirmed as VQTL (459.351 Da) and LGYEN (594.276 Da) by UPLC-ESI-MS/MS. ARTICLE HISTORY

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“…Wakame seaweed (Undaria pinnatifida) is the most popular, edible seaweed in Japan [251] . In humans, 3.3 g of dried Wakame for four wk significantly reduced both the SBP 14 ± 3 mmHg and the DBP 5 ± 2 mmHg (p < 0.01) [252] .…”

Section: Seaweedmentioning

confidence: 99%

“…Seaweed and sea vegetables contain most all of the seawater's 77I minerals and rare earth elements, fiber and alginate in a colloidal form [251][252][253] . The primary effect of Wakame appears to be through its ACEI activity from at least four parent tetrapeptides and possibly their dipeptide Houston M. Hypertension, nutrition, nutritional supplements, cardiovascular disease and tripeptide metabolites, especially those containing the amino acid sequence Val-Tyr, Ile-Tyr, Phe-Tyr and Ile-Try in some combination [251,254,255] .…”

Section: Seaweedmentioning

confidence: 99%

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Houston¹

2014

WJC

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Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrientgene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypertension; Nutrition; Nutritional supplements; Cardiovascular disease; Vascular biology Core tip: Vascular biology and endothelial dysfunction play a primary roles in hypertension and subsequent cardiovascular disease. Micronutrients, macronutrients and optimal nutrition and nutritional supplements can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. These treatments are complementary to drug therapy. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol 2014; 6(2): 38-66 Available from:

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Identification of an antihypertensive peptide from peptic digest of wakame (Undaria pinnatifida)

Cited by 225 publications

References 23 publications

Optimization of some conditions of Neutrase-catalyzed plastein reaction to mediate ACE-inhibitory activity in vitro of casein hydrolysate prepared by Neutrase

Optimization of some conditions of Neutrase-catalyzed plastein reaction to mediate ACE-inhibitory activity in vitro of casein hydrolysate prepared by Neutrase

Purification and identification of angiotensin I-converting enzyme inhibitory peptides from fermented walnut residues

The role of nutrition and nutraceutical supplements in the treatment of hypertension

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