Identification of an autocrine negative growth factor: Mouse β-galactoside-binding protein is a cytostatic factor and cell growth regulator

Wells, Valerie; Mallucci, Livio

doi:10.1016/0092-8674(91)90211-g

Cited by 229 publications

(140 citation statements)

References 27 publications

Supporting

Mentioning

135

Contrasting

Unclassified

Order By: Relevance

“…In general, lectins exert their biological effects by binding to certain carbohydrate structures. Galectin-1's carbohydrate-binding ability is required for some functions but not others (27,39,51,52). The present study suggests that the carbohydrate-binding activity of Galectin-1 is required for its promotion of adult neural progenitor cell proliferation.…”

Section: Galectin-1-null Mice Have Fewer Neural Progenitor Cells In Tmentioning

confidence: 67%

A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells

Sakaguchi

Shingo

Shimazaki³

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

144

150

View full text Add to dashboard Cite

In the subventricular zone of the adult mammalian forebrain, neural stem cells (NSCs) reside and proliferate to generate young neurons. We screened factors that promoted the proliferation of NSCs in vitro by a recently developed proteomics technique, the ProteinChip system. In this screen, we identified a soluble carbohydrate-binding protein, Galectin-1, as a candidate. We show herein that Galectin-1 is expressed in a subset of slowly dividing subventricular zone astrocytes, which includes the NSCs. Based on results from intraventricular infusion experiments and phenotypic analyses of knockout mice, we demonstrate that Galectin-1 is an endogenous factor that promotes the proliferation of NSCs in the adult brain.lectin ͉ mobilization ͉ stem cell niche

show abstract

Section: Galectin-1-null Mice Have Fewer Neural Progenitor Cells In Tmentioning

confidence: 67%

A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells

Sakaguchi

Shingo

Shimazaki³

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

144

150

View full text Add to dashboard Cite

show abstract

“…Among them, galactose-binding lectins play roles in cell differentiation [3], apoptosis [4], recognition of tumor antigens [5], and uptake of galactosylated glycoproteins [6]. In host defense, the recognition of bacterial components is important for induction of immune responses.…”

Section: Introductionmentioning

confidence: 99%

Intelectin gene from the grass carp Ctenopharyngodon idella: cDNA cloning, tissue expression, and immunohistochemical localization

Chang

Nie

2007

Fish & Shellfish Immunology

View full text Add to dashboard Cite

“…Galectin-1 has been shown to bind with laminin and to inhibit cell-matrix interactions (18), which are mediated via the laminin receptor integrin ␣ 7 ␤ 1 (19). Galectin-1 also plays a role in cell proliferation (20), cell migration (21), immunologic modulation and apoptosis in PHA-stimulated peripheral T cells (22,23), carcinogenesis (24), and embryogenesis (25). Galectin-3 recognizes certain specific ligands (e.g., IgE, reference 26 and laminin, reference 27), and mediates a multitude of biological functions, including bacterial colonization (28), superoxide production of neutrophils (29), acting as a pre-mRNA-splicing factor (30), regulation of T cell growth and apoptosis (31), and carcinogenesis (32).…”

Section: Introductionmentioning

confidence: 99%

Developmental regulation, expression, and apoptotic potential of galectin-9, a beta-galactoside binding lectin.

Wada¹,

Ota²,

Kumar³

et al. 1997

J. Clin. Invest.

255

198

View full text Add to dashboard Cite

Galectin-9, a ␤ -galactoside binding lectin, has recently been isolated from murine embryonic kidney. In this study, its biological functions and expression in embryonic, newborn, and adult mice tissues were investigated. By Northern blot analyses, it was found widely distributed and its expression was developmentally regulated. In situ hybridization studies revealed an accentuated expression of galectin-9 in liver and thymus of embryonic mice. In postnatal mice, antigalectin-9 immunoreactivity was observed in various tissues, including thymic epithelial cells. The high expression of galectin-9 in the thymus led us to investigate its role in the clonal deletion of thymocytes. Fusion proteins were generated, which retained lactose-binding activity like the endogenous galectin-9. Galectin-9, at 2.5 M concentration, induced apoptosis in ‫ف‬ 30% of the thymocytes, as assessed by terminal deoxytransferase-mediated dUTP nick end labeling method. The apoptotic effect was dose dependent and lactose inhibitable. At higher concentrations, it induced homotypic aggregation of the thymocytes. Electron microscopy revealed ‫ف‬ 60% of the thymocytes undergoing apoptosis in the presence of galectin-9. By immunofluorescence microscopy, some of the thymocytes undergoing apoptosis had plasmalemmal bound galectin-9. Galectin-9 failed to induce apoptosis in hepatocytes. Taken together, these findings indicate that galectin-9, a developmentally regulated lectin, plays a role in thymocyte-epithelial interactions relevant to the biology of the thymus. ( J. Clin. Invest. 1997. 99:2452-2461.)

show abstract

Identification of an autocrine negative growth factor: Mouse β-galactoside-binding protein is a cytostatic factor and cell growth regulator

Cited by 229 publications

References 27 publications

A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells

A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells

Intelectin gene from the grass carp Ctenopharyngodon idella: cDNA cloning, tissue expression, and immunohistochemical localization

Developmental regulation, expression, and apoptotic potential of galectin-9, a beta-galactoside binding lectin.

Contact Info

Product

Resources

About