Identification of an imipenem-resistant Pseudomonas aeruginosa clone among patients in a hospital in Rio de Janeiro

Kokis, V. M.; Moreira, Beatriz Meurer; Pellegrino, Flávia Lúcia Piffano Costa; Silva, M.G.; Long, Janet B.; Bastos, C.C.R.; Santos, Kátia Regina Netto dos

doi:10.1016/j.jhin.2004.11.019

Cited by 11 publications

(10 citation statements)

References 14 publications

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“…This result is comparable to other studies, which showed high rates (79%) of resistance to this antibiotic among IRPA isolates (Kokis et al, 2005;Pinar et al, 2008;Sanchez-Romero et al, 2003). The low percentages of susceptibility to fluroquinolones may reflect the high use of these antimicrobials in the hospital settings.…”

Section: Discussionsupporting

confidence: 89%

“…The resistance rates for those antibiotics were lower than previous reports (Kokis et al, 2005) which demonstrated higher values (71 to 79%). In our study less than 50% of the carbapenem-resistant isolates were also resistant to amikacin (28.3%), ceftazidime (36.7%) and tazocin (18.3%).…”

Section: Discussioncontrasting

confidence: 73%

“…Tel: 01-467-1088Tel: 01-467- /467-1010 aeruginosa, due to their stability to ambler classes A, C and D ß -lactamases compared with other ß -lactams. However, over use of imipenem has been associated with the isolation of P. aeruginosa strains producing class B enzymes (IMP and VIM), called metallo-ß -lactamases that are able to hydrolyse all broad-spectrum -ß lactams except monobactams (Kokis et al, 2005), such resistance can be chromosomally encoded or plasmid mediated.…”

Section: Introductionmentioning

confidence: 99%

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Imipenem-resistant Psedomonas aeruginosa: Epidemiology and susceptibility patterns at a Teaching Hospital in Riyadh, Saudi Arabia

Otaibi¹,

Al-Hulaily²

2012

Afr. J. Microbiol. Res.

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Pseudomonas aeruginosa is an important nosocomial pathogen. It causes high morbidity and mortality. The incidence of imipenem-resistance is increasing among Gram negative bacilli, particularly P. aeruginosa, often associated with resistance to other antipseudomonal drugs. The aim of this study is to assess potential risk factors for nosocomial infections of imipenem-resitant P. aeruginosa (IRPA), and to obtain base line information on the epidemiology and susceptibility pattern of this important pathogen. In a retrospective study of patients with nosocomial P. aeruginosa infection from July 2008 to August 2010 in a tertiary care hospital in Riyadh, Saudi Arabia, the imipenem susceptibility of 381 nosocomial P. aeruginosa isolates was evaluated by disk diffusion method and confirmed by determining minimum inhibitory concentration (MIC) using E test. Antimicrobial susceptibility testing for other antibiotics was performed. The features of the patients with IRPA infections were compared to those with imipenem-sensitive P. aeruginosa (ISPA) infections. During the study period, IRPA was isolated from 60 (15.7%) of patients, and the ISPA was isolated from 321 (84.3%) patients. IRPA were most frequently isolated from urine (23.3%) cultures (p=0.01), whereas ISPA were most frequently isolated from swab (57.6%) cultures (p=0.04). Risk factors that were significantly associated with IRPA included: surgery (p=0.001), diabetes mellitus (p=0.04), and trauma (p=0.01). Overall, the highest P. aeruginosa rate (33%) was obtained in the medical ward followed by ICU (29%), surgical ward (28.3%), oncology (5.5%), burn unit (3%), and renal dialysis unit (2.4%). ICU patients accounted for 21(35%) of IRPA infected patients. All tested antipseudomonal agents, demonstrated higher resistance rates among IRPA isolates than ISPA isolates (p=0.001). Pipracillin/tazobactam was the most active agent for both groups followed by amikacin and ceftazidime. No significant difference in the mortality rate between the imipenem-resistant and susceptible groups. Isolates of P. aeruginosa that are resistant to all, or almost all, available antibiotics "panresistant" are now prevalent worldwide. Our study showed that imipenem-resistance in this clinical pathogen is an emerging problem. Periodical surveillance studies are therefore essential to determine the current susceptibility patterns of P. aeruginosa to different antimicrobial agents, and to identify risk factors for acquisition of carbapenem-resistant strains.

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Section: Discussionsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

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Imipenem-resistant Psedomonas aeruginosa: Epidemiology and susceptibility patterns at a Teaching Hospital in Riyadh, Saudi Arabia

Otaibi¹,

Al-Hulaily²

2012

Afr. J. Microbiol. Res.

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“…Otherwise parenteral therapy is necessary and includes ceftazidime, aminoglycosides, meropenem, piperacillin/tazobactam, and ticarcillin/ clavulanate [9]. Resistance to Imipenem was noted [14].…”

Section: Resultsmentioning

confidence: 99%

“…Nevertheless, imipenam resistant Pseudomonas appears as a new challenging problem especially in hospitalized patient [13]. Imipenem resistance was observed in (61.2%) of the isolates in Brazil [14].…”

Section: Introductionmentioning

confidence: 99%

Diabetic Foot Infections with Pseudomonas: Jabir Abueliz Diabetic Center Khartoum Experience

Wahab¹,

Bakhiet²,

Mahadi³

et al. 2014

Clin Res Foot Ankle

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Clinical, microbiologic, and epidemiologic characteristics of Pseudomonas aeruginosa infections in a University Hospital, Malatya, Turkey

Yetkin¹,

Otlu²,

Çiçek³

et al. 2006

American Journal of Infection Control

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Identification of an imipenem-resistant Pseudomonas aeruginosa clone among patients in a hospital in Rio de Janeiro

Cited by 11 publications

References 14 publications

Imipenem-resistant Psedomonas aeruginosa: Epidemiology and susceptibility patterns at a Teaching Hospital in Riyadh, Saudi Arabia

Imipenem-resistant Psedomonas aeruginosa: Epidemiology and susceptibility patterns at a Teaching Hospital in Riyadh, Saudi Arabia

Diabetic Foot Infections with Pseudomonas: Jabir Abueliz Diabetic Center Khartoum Experience

Clinical, microbiologic, and epidemiologic characteristics of Pseudomonas aeruginosa infections in a University Hospital, Malatya, Turkey

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