2022
DOI: 10.21203/rs.3.rs-1301179/v1
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Identification of an inhibitory pocket in falcilysin bound by chloroquine provides a new avenue for malaria drug development

Abstract: Despite their widespread use, our understanding of how malaria drugs work remains limited. This includes chloroquine (CQ), the most successful antimalarial ever deployed. Here, we used MS-CETSA and dose-response transcriptional profiling to identify possible protein targets and mechanism of action (MOA) of CQ, as well as MK-4815, a malaria drug candidate with a proposed MOA similar to CQ. Both compounds bind falcilysin (FLN) and hemoglobin digestion was the key biological pathway affected, with distinct MOA pr… Show more

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