Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular cells
Yihong Chen,
Chrysostomi Gialeli,
Junyan Shen
et al.
Abstract:Background: The osteopontin-derived peptide FOL-005 has been shown to stimulate hair growth. Using ligand-receptor glycocapture technology we identified neuropilin-1 (NRP-1), a known co-receptor for vascular endothelial growth factor (VEGF) receptors, as the most probable receptor for FOL-005. Considering that induction of perifollicular angiogenesis by VEGF is a critical step in activation of the anagen growth phase of hair follicles, we investigated the effect of the more stable FOL-005 analogue FOL-026 on v… Show more
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