Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis

Chen, Yihong; Gialeli, Chrysostomi; Shen, Junyan; Dunér, Pontus; Walse, Björn; Duelli, Annette; Caing-Carlsson, Rhawnie; Blom, Anna M.; Zibert, John R.; Nilsson, Anna Hultgårdh; Alenfall, Jan; Liang, Chun; Nilsson, Jan

doi:10.1016/j.phrs.2024.107259

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article1

Preprint1

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Ultrasensitive and label-free electrochemical immunosensor using gold nanoparticles deposited on a carbon electrode for the quantification of osteopontin: A serum-based oncomarker

Ahmad,

Rabbani,

Hosawi

et al. 2025

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Ultrasensitive and label-free electrochemical immunosensor using gold nanoparticles deposited on a carbon electrode for the quantification of osteopontin: A serum-based oncomarker

Ahmad,

Rabbani,

Hosawi

et al. 2025

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

The Role of Moracin M in Promoting Hair Growth: Insights into Mechanisms of WNT/β- Catenin Pathway Activation and Angiogenesis Enhancement in Human Dermal Papilla Cells

Chang,

Hwang,

Kim

et al. 2024

Preprint

View full text Add to dashboard Cite

Hair follicle growth depends on the intricate interaction of cells within the follicle and its vascular supply. Current FDA-approved treatments like minoxidil have limitations, including side effects and the need for continuous use. Moracin M, a compound from Moraceae family, was investigated for its effects on hair growth and vascular regeneration. In our study, Moracin M significantly increased cell proliferation in human dermal papilla cells (hDPCs) during both the anagen and catagen phases and promoted cell migration in human umbilical vein endothelial cells (HUVECs) without cytotoxicity at concentrations up to 50 µM. Mechanistic analysis revealed that moracin M enhanced GSK-3β phosphorylation and increased non-phospho β-catenin levels, activating Wnt signaling and upregulating transcription factors LEF, TCF, and AXIN2. This resulted in elevated levels of growth factors VEGF, FGF2, KGF, HGF and MYC in hDPCs, effects comparable to those of minoxidil. Additionally, moracin M significantly increased protein and mRNA levels of VEGF, FGF2, and KGF in hDPCs under IFN-γ-induced inflammatory conditions. Moracin M treatments also resulted in notable wound width reductions in a dose-dependent manner. Further investigation showed that moracin M stimulated MMP-2 and MMP-9 expression while having no effect on MMP-7 levels. These findings indicate that moracin M significantly enhances hair growth through the promotion of cell proliferation and angiogenesis, particularly via the activation of the Wnt signaling pathway in dermal papilla cells, presenting it as a promising therapeutic alternative to current treatments.

show abstract

Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis

Cited by 2 publications

References 44 publications

Ultrasensitive and label-free electrochemical immunosensor using gold nanoparticles deposited on a carbon electrode for the quantification of osteopontin: A serum-based oncomarker

Ultrasensitive and label-free electrochemical immunosensor using gold nanoparticles deposited on a carbon electrode for the quantification of osteopontin: A serum-based oncomarker

The Role of Moracin M in Promoting Hair Growth: Insights into Mechanisms of WNT/β- Catenin Pathway Activation and Angiogenesis Enhancement in Human Dermal Papilla Cells

Contact Info

Product

Resources

About