Identification of Angiotensin-Converting Enzyme Inhibitory Proteins from Mycelium of Pleurotus pulmonarius (Oyster Mushroom)

Ibadallah, Badjie Xietaqieuallah; Abdullah, Noorlidah; Shuib, Adawiyah Suriza

doi:10.1055/s-0034-1383409

Cited by 18 publications

(5 citation statements)

References 43 publications

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“…ACE inhibitory activity of mushrooms, the genus Pleurotus, is confirmed by a number of studies. Available data on ACE inhibitory activity focus on the action of proteins and bioactive peptides [67,68].…”

Section: Ace Inhibitory Activitymentioning

confidence: 99%

Effects of Various Drying Methods on Some Physico-Chemical Properties and the Antioxidant Profile and ACE Inhibition Activity of Oyster Mushrooms (Pleurotus Ostreatus)

Piskov

Timchenko

Grimm

et al. 2020

Foods

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In food biotechnology, Pleurotus ostreatus is of great interest as a source of natural antioxidants and angiotensin-converting enzyme (ACE) inhibitors. However, research in this area has not yet been completed. The effect of various drying methods on the structural properties and the rehydration capacity of mushrooms was investigated in this paper. The content of secondary metabolites, the peptide profile, and the antioxidative effect and ACE inhibitory activity of dry mushrooms were investigated in vitro, simulating the process of gastrointestinal digestion. X-ray microtomography has confirmed that structure of lyophilic and sun-dried mushrooms is dominated by open pores, and in mushrooms dried with hot air and microwave, closed pores. Experiments have shown that the conditions of freeze drying and sun drying of Pleurotus ostreatus provide a higher rehydration capacity of dried mushrooms. The maximum activity of radical absorption of the oyster mushroom after microwave drying was observed. The iron restoring capacity of the mushrooms is maximally maintained with microwave drying and hot-air drying. The properties of the antioxidant product with an emphasis on the high activity of inhibiting lipid oxidation of the mushroom maximized after drying in the sun. Mushrooms dried lyophilically and in the sun showed the highest ACE inhibitory activity.

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Section: Ace Inhibitory Activitymentioning

confidence: 99%

Effects of Various Drying Methods on Some Physico-Chemical Properties and the Antioxidant Profile and ACE Inhibition Activity of Oyster Mushrooms (Pleurotus Ostreatus)

Piskov

Timchenko

Grimm

et al. 2020

Foods

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“…Glucans in P. pulmonarius mycelium extracts exhibited the anti-inflammatory effect by blocking TNF-α-induced NF-κB nuclear translocation [42] . In addition, ACE inhibitory proteins have been identified in mycelium of P. pulmonarius [43] . Although glucose and galactose are prominent polysaccharides in fungal mycelium [44] , it is not determined which carbon-rich molecules in P. pulmonarius mycelium act as prebiotics to induce the fermentation of L. rhamnosus EH8.…”

Section: Discussionmentioning

confidence: 99%

Gut probiotic Lactobacillus rhamnosus attenuates PDE4B-mediated interleukin-6 induced by SARS-CoV-2 membrane glycoprotein

Pham

Yang

Kao

et al. 2021

The Journal of Nutritional Biochemistry

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Membrane glycoprotein is the most abundant protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but its role in coronavirus disease 2019 (COVID-19) has not been fully characterized. Mice intranasally inoculated with membrane glycoprotein substantially increased the interleukin (IL)-6, a hallmark of the cytokine storm, in bronchoalveolar lavage fluid (BALF), compared to mice inoculated with green fluorescent protein (GFP). The high level of IL-6 induced by membrane glycoprotein was significantly diminished in phosphodiesterase 4 (PDE4B) knockout mice, demonstrating the essential role of PDE4B in IL-6 signaling. Mycelium fermentation of Lactobacillus rhamnosus ( L. rhamnosus ) EH8 strain yielded butyric acid, which can down-regulate the PDE4B expression and IL-6 secretion in macrophages. Feeding mice with mycelia increased the relative abundance of commensal L. rhamnosus. Two-week supplementation of mice with L. rhamnosus plus mycelia considerably decreased membrane glycoprotein-induced PDE4B expression and IL-6 secretion. The probiotic activity of L. rhamnosus plus mycelia against membrane glycoprotein was abolished in mice treated with GLPG-0974, an antagonist of free fatty acid receptor 2 (Ffar2). Activation of Ffar2 in the gut-lung axis for down-regulation of the PDE4B-IL-6 signalling may provide targets for development of modalities including probiotics for treatment of the cytokine storm in COVID-19.

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“…Another peptide with ACE inhibitory activity was isolated from the hot water extract of G. frondosa with the following amino acid sequence Val‐Ile‐Glu‐Lys‐Tyr‐ Pro. Additionally, proteins present in P. pulmonarius also have antihypertensive effects by inhibiting ACE (Ibadallah et al., 2015), which is responsible for converting inactive Ang I protein into active Ang II. The renin‐angiotensin‐angiotensin II system has a range of multiple effects on blood pressure maintenance by increasing sodium and water retention through the release of aldosterone.…”

Section: Nutraceutical Potential Of Mushroom Bioactive Metabolitesmentioning

confidence: 99%

Nutraceutical potential of mushroom bioactive metabolites and their food functionality

Ishara

Buzera

Mushagalusa

et al. 2021

Journal of Food Biochemistry

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Numerous mushroom bioactive metabolites, including polysaccharides, eritadenine, lignin, chitosan, mevinolin, and astrakurkurone have been studied in life‐threatening conditions and diseases such as diabetes, cardiovascular, hypertension, cancer, DNA damage, hypercholesterolemia, and obesity attempting to identify natural therapies. These bioactive metabolites have shown potential as antiviral and immune system strengthener natural agents through diverse cellular and physiological pathways modulation with no toxicity evidence, widely available, and inexpensive. In light of the emerging literature, this paper compiles the most recent information describing the molecular mechanisms that underlie the nutraceutical potentials of these mushroom metabolites suggesting their effectiveness if combined with existing drug therapies while discussing the food functionality of mushrooms. The findings raise hope that these mushroom bioactive metabolites may be utilized as natural therapies considering their therapeutic potential while anticipating further research designing clinical trials and developing new drug therapies while encouraging their consumption as a natural adjuvant in preventing and controlling life‐threatening conditions and diseases. Practical applications Diabetes, cardiovascular, hypertension, cancer, DNA damage, hypercholesterolemia, and obesity are among the world's largest life‐threatening conditions and diseases. Several mushroom bioactive compounds, including polysaccharides, eritadenine, lignin, chitosan, mevinolin, and astrakurkurone have been found potential in tackling these diseases through diverse cellular and physiological pathways modulation with no toxicity evidence, suggesting their use as nutraceutical foods in preventing and controlling these life‐threatening conditions and diseases.

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Identification of Angiotensin-Converting Enzyme Inhibitory Proteins from Mycelium of Pleurotus pulmonarius (Oyster Mushroom)

Cited by 18 publications

References 43 publications

Effects of Various Drying Methods on Some Physico-Chemical Properties and the Antioxidant Profile and ACE Inhibition Activity of Oyster Mushrooms (Pleurotus Ostreatus)

Effects of Various Drying Methods on Some Physico-Chemical Properties and the Antioxidant Profile and ACE Inhibition Activity of Oyster Mushrooms (Pleurotus Ostreatus)

Gut probiotic Lactobacillus rhamnosus attenuates PDE4B-mediated interleukin-6 induced by SARS-CoV-2 membrane glycoprotein

Nutraceutical potential of mushroom bioactive metabolites and their food functionality

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