Identification of Antidiabetic Effect of Iridoid Glycosides and Low Molecular Weight Polyphenol Fractions of Corni Fructus, a Constituent of Hachimi-jio-gan, in Streptozotocin-Induced Diabetic Rats

Yamabe, Noriko; Kang, Ki Sung; Matsuo, Yosuke; Tanaka, Takashi; Yokozawa, Takako

doi:10.1248/bpb.30.1289

Cited by 80 publications

(65 citation statements)

References 38 publications

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“…This polyphenolic compound showed beneficial effect on the early stage of the diabetic kidney disease [79]. GS reduced renal glucose, AGE formation, and oxidative stress in diabetic rats.…”

Section: Benzoic Acid Derivativesmentioning

confidence: 90%

Plant-Derived Agents with Anti-Glycation Activity

Odjakova¹,

Popova²,

Sharif³

et al. 2012

Glycosylation

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“…This polyphenolic compound showed beneficial effect on the early stage of the diabetic kidney disease [79]. GS reduced renal glucose, AGE formation, and oxidative stress in diabetic rats.…”

Section: Benzoic Acid Derivativesmentioning

confidence: 90%

Plant-Derived Agents with Anti-Glycation Activity

Odjakova¹,

Popova²,

Sharif³

et al. 2012

Glycosylation

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“…The doses of morroniside were the same as our previous study using streptozotocin-induced diabetic rats, 17) which were determined according to our studies of Corni Fructus 14) and its fractions. 18) The body weight, food intake, and water intake were measured everyday during the treatment period. After 8 weeks of morroniside treatment, blood samples were collected by the cardiac puncture of anesthetized mice.…”

Section: Methodsmentioning

confidence: 99%

The Beneficial Effects of Morroniside on the Inflammatory Response and Lipid Metabolism in the Liver of <i>db</i>/<i>db</i> Mice

Park

Yamabe

Noh

et al. 2009

Biological & Pharmaceutical Bulletin

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Diabetes mellitus is a major cause of mortality and morbidity worldwide, and its prevalence is increasing at an alarming rate. Hyperglycemia and dyslipidemia lead to complications associated with diabetes mellitus, and, also, the attenuation of oxidative stress and regulation of stress-sensitive signaling pathways have been considered as ways to alleviate diabetes. [1][2][3][4] Hyperglycemia causes oxidative stress by two mechanisms: first, by decreasing the regeneration of the important cellular antioxidant, reduced glutathione (GSH) from oxidized glutathione (GSSG), and second, by decreasing the availability of reduced nicotinamide adenine dinucleotide phosphate (NADPH). Furthermore, hyperglycemia-induced reactive oxygen species (ROS) stimulate the activation of protein kinase C (PKC), formation of advanced glycation endproducts (AGE), and sorbitol accumulation. Also, increased ROS lead to the activation of nuclear factor-kappa B (NF-kB), and activated NF-kB can enhance the expression of proinflammatory cytokines, chemokines, adhesion molecules, inflammatory receptors, and inflammatory enzymes such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). 5-7)Dyslipidemia is the abnormal state of elevated cholesterol, triglyceride, and low-density lipoprotein or decreased highdensity lipoprotein in the plasma level that contribute to the development of atherosclerosis. Dyslipidemia is a risk factor for coronary artery disease, a leading cause of mortality in patients with diabetes mellitus. [8][9][10] Triglyceride is involved in the ectopic accumulation of lipid stores in the liver and are associated with a number of diseases such as metabolic syndrome and type 2 diabetes. Critical players in potentiating the promoting effect of hyperinsulinemia on hepatic lipid accumulation are the anabolic transcription factor peroxisome proliferator activated receptor a (PPARa) and sterol regulatory element binding proteins (SREBPs), which upregulate genes such as those for fatty acid synthase and cholesterol levels. [11][12][13] Corni Fructus (Cornus officinalis SIEB. et ZUCC.) is a rich source of iridoid glycosides in traditional medicine.14) Iridoids are a group of natural products belonging to the terpenoids, which are ubiquitous in plants. However, only a limited number of taxa possess the enzymes that give rise to the cyclopentane ring that is characteristic of the carbocyclic iridoids.15) Morroniside is a carbocyclic iridoid glycoside which has been reported to exhibit marked antioxidant activity. 16) In our previous studies, we reported the beneficial effect of morroniside on streptozotocin-induced type 1 diabetic renal damage. The administration of morroniside could ameliorate hyperglycemia, renal oxidative stress, and inflammation in diabetic rats. 17) However, the effect of morroniside on the type 2 diabetic liver, especially in dyslipidemia, has not yet been determined. The liver is an important organ for maintaining glucose metabolism and lipid homeostasis, since it can store (via glycogen synthes...

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“…It was previously discovered that Corni Fructus could ameliorate glucose-associated metabolic disorders (47). Their mechanisms were intimately related to the formation of advancedglycation end products (AGEs) (51).…”

Section: Loganic Acid and Loganinmentioning

confidence: 99%

Glycogen Phosphorylase-a is a Common Target for Anti-Diabetic Effect of Iridoid and Secoiridoid Glycosides

et al. 2013

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-Purpose. Diabetes mellitus is characterized by hyperglycemia resulting from defects in insulin secretion, action or both. The use of medicinal plants for the treatment of diabetes mellitus dates back from the Ebers papyrus of about 1550 B.C. One of the major problems with herbal drugs is that the active ingredients are not well defined. It is important to know the active components and their molecular interactions which will help to analyze their therapeutic efficacy and also to standardize the product. There are a number of medicinal plants known for their anti-diabetic effect that possess similarities in their active chemical components, e.g. iridoid and secoiridoid glycosides. Methods. In this study, we have compared the structure of various iridoid and secoiridoid glycosides to design a novel pharmacophore. We further developed a structure-activity relationship for the inhibition of glycogen phosphorylase-a. Conclusion. By using docking studies, we are proposing, for the first time, that inhibition of glycogen phosphorylase-a activity is a common target for iridoids and secoiridoids to elicit anti-diabetic effects.

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Identification of Antidiabetic Effect of Iridoid Glycosides and Low Molecular Weight Polyphenol Fractions of Corni Fructus, a Constituent of Hachimi-jio-gan, in Streptozotocin-Induced Diabetic Rats

Cited by 80 publications

References 38 publications

Plant-Derived Agents with Anti-Glycation Activity

Plant-Derived Agents with Anti-Glycation Activity

The Beneficial Effects of Morroniside on the Inflammatory Response and Lipid Metabolism in the Liver of <i>db</i>/<i>db</i> Mice

Glycogen Phosphorylase-a is a Common Target for Anti-Diabetic Effect of Iridoid and Secoiridoid Glycosides

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