Identiﬁcation of antioxidant compound from <i>Asparagus racemosus</i>

Wiboonpun, Nathathai; Phuwapraisirisan, Preecha; Tip‐pyang, Santi

doi:10.1002/ptr.1526

Cited by 78 publications

(55 citation statements)

References 9 publications

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“…It is mainly known for its phytoestrogenic properties. In Ayurveda, Asparagus racemosus has been used extensively as an adaptogen to increase the nonspecific resistance of organisms against a variety of stresses (Visavadiya et al, 2009;Wiboonpun et al, 2004). Besides use in the treatment of diarrhoea and dysentery, the plant also has antioxidant, immunestimulant, anti-dyspepsia and anti-tussive effects (Visavadiya et al, 2009;Wiboonpun et al, 2004;Kamat et al, 2000;Ojha et al, 2010;Gautam et al, 2009;Mandal et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Investigation of cytotoxicity and in-vitro antioxidant activity of Asparagus racemosus root extract

et al. 2012

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This attempt is made to address the phytoconstituents, free radical scavenging activity and brine shrimp lethality bioassay of five different extracts of Asparagus racemosus roots. Preliminary phytochemical examination of the crude extracts of Asparagus racemosus root disclosed the existence of different sort of chemical groups such as flavonoids, tannin, saponin, alkaloids, carbohydrate. The root displayed significant DPPH free radical scavenging activity with highest IC50 value showed by ethanol extract with a value of 78.15 µg/ml followed by methanol and petroleum ether having value of 106.44 µg/ml and 273.31 µg/ml respectively as opposed to that of the scavenging effects of ascorbic acid and BHT of 5.698 µg/ml and 8.816 µg/ml respectively. The highest reducing power was showed by ethanol extract followed by methanol and petroleum ether as opposed to that of the reducing potential of ascorbic acid and BHT. The fractions represented good cupric reducing capacity with increasing concentration taking ethanol extract in the top position. The ethanol extract yielded 108.78±2.77 mg/gm gallic acid equivalent phenolic content and methanol sub-fraction yielded 164.77±1.73 mg/gm quercetin equivalent flavonoid content that was highest among five extracts. Ethanol extract of Asparagus racemosus was found to possess the highest total antioxidant capacity (639.925±64.78) mg/gm followed by methanol (616.92±53.88) mg/gm and petroleum ether (469.17±52.95) mg/gm ascorbic acid equivalent respectively. In brine shrimp lethality bioassay, LC50 values for ethanol, methanol, petroleum ether, n-hexane and chloroform were found to be 0.674 µg/ml, 0.719 µg/ml, 0.984 µg/ml, 2.157µg/ml and 1.514 µg/ml respectively. N-hexane and chloroform extract showed least activity in all the measures. The results suggest that Asparagus racemosus is a valuable source of antioxidant and has significant cytotoxic activity hence could eliminate many diseases related to free radical.DOI: http://dx.doi.org/10.3329/icpj.v1i9.11615 International Current Pharmaceutical Journal 2012, 1(9): 250-257

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Section: Introductionmentioning

confidence: 99%

Investigation of cytotoxicity and in-vitro antioxidant activity of Asparagus racemosus root extract

et al. 2012

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“…The antioxidant properties were mainly exhibited due to the presence of Isoflavons (Wiboonpun et al, 2004).…”

Section: Antioxidant Actionmentioning

confidence: 99%

Pharmacological Profile of Asparagus racemosus: A Review

Shaha¹,

Bellankimath²

2017

Int.J.Curr.Microbiol.App.Sci

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“…Five steroidal saponins, shatavarins VI-X, together with five known saponins, shatavarin I (or asparoside B), shatavarin IV (or asparinin B), shatavarin V, immunoside and schidigerasaponin D5 (or asparanin A), are the chemical constituent available roots of Asparagus racemosus [4]. Three more steroidal saponins, racemosides A (1), B (2) and C (3), are seen in the fruits of Asparagus racemosus [5,6].…”

Section: Definition Of the Problemmentioning

confidence: 99%

Isolation, structure elucidation and biotransformation studies on secondary metabolites from Asparagus racemosus

VS¹,

AS²

2010

Int J of Micr Res

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-Asparagus racemosus is important medicinal plant of tropical and subtropical India, is a potent phytoestrogen, which is used extensively in the treatment of menopausal symptoms, diarrhea, dyspepsia, and neurodegenerative disorders. The multiple uses of this species have increased its commercial demand resulting in over-exploitation. Consequently, the plant is recognized as being "critically endangered" in its natural habitat. Development of an efficient Isolation, structure elucidation and biotransformation studies protocol will not only play a significant role in meeting the requirement of planting material for commercial cultivation, but also in aiding the conservation process.

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Identiﬁcation of antioxidant compound from Asparagus racemosus

Cited by 78 publications

References 9 publications

Investigation of cytotoxicity and in-vitro antioxidant activity of Asparagus racemosus root extract

Investigation of cytotoxicity and in-vitro antioxidant activity of Asparagus racemosus root extract

Pharmacological Profile of Asparagus racemosus: A Review

Isolation, structure elucidation and biotransformation studies on secondary metabolites from Asparagus racemosus

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