Identification of Biomarkers Associated with Cancer Using Integrated Bioinformatic Analysis

Abstract

Among the leading cause of death cancer ranked in top position. Early diagnosis of cancer holds promise for reduced mortality rate and speedy recovery. The cancer associated molecules being altered in terms of under/over expression when compared to normal cells and thus could act as biomarkers for therapeutic designing and drug repurposing. The information about the known cancer associated biomarkers can be exploited for targeting of cancer specifically in terms of selective personalized medicine designing. This chapter deals with various types of biomarkers associated with different types of cancer and their identification using integrated bioinformatic analysis. Besides, a brief insight on integrated bioinformatics analysis tools and databases have also been discussed.

Next-Generation Intelligent MXene-Based Electrochemical Aptasensors for Point-of-Care Cancer Diagnostics

“…Various other analytical techniques such as polymerase chain reaction (PCR), immunohistochemistry, flow cytometry have been used for the evaluation of cancer biomarkers; however, they lack acceptable sensitivity and need sophisticated instrumentation facilities with long run time. Biosensors-based detection of biomarkers can be used efficiently for the early diagnosis of cancer disease [ 15 , 20 , 23 ]. The use of biorecognition elements (BREs) such as an antibody, aptamers, enzymes with conjugation to biomarkers associated with cancer cells enhanced the selectivity and sensitivity of the detection technique [ 82 ].…”

“…Biomarker’s study can be benefited in multiple ways such as risk assessment [ 8 ], diagnosis [ 9 ], prognosis [ 10 ], predicting the treatment efficiency [ 11 ], toxicity [ 12 ], recurrence of any type of tumor, and many more [ 13 ]. The identification of biomarkers associated with a specific type of cancer can help to develop reliable and cost-effective diagnostics to detect cancer at an early stage and monitor it throughout the process of treatment [ 6 , 14 , 15 ]. For cancer diagnosis, conventional techniques such as PET, CT, X-ray, mammography, and tissue biopsy are the mainstream diagnostic modality being still used.…”