2023
DOI: 10.3389/fimmu.2023.1146693
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Identification of biomarkers co-associated with M1 macrophages, ferroptosis and cuproptosis in alcoholic hepatitis by bioinformatics and experimental verification

Abstract: BackgroundsAlcoholic hepatitis (AH) is a major health problem worldwide. There is increasing evidence that immune cells, iron metabolism and copper metabolism play important roles in the development of AH. We aimed to explore biomarkers that are co-associated with M1 macrophages, ferroptosis and cuproptosis in AH patients.MethodsGSE28619 and GSE103580 datasets were integrated, CIBERSORT algorithm was used to analyze the infiltration of 22 types of immune cells and GSVA algorithm was used to calculate ferroptos… Show more

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Cited by 8 publications
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“…Western blot analysis was performed as described previously ( 30 ). Total protein was extracted by RIPA lysis buffer (Beyotime, Beijing, China) and quantified by bicinchoninic acid (BCA) method.…”
Section: Methodsmentioning
confidence: 99%
“…Western blot analysis was performed as described previously ( 30 ). Total protein was extracted by RIPA lysis buffer (Beyotime, Beijing, China) and quantified by bicinchoninic acid (BCA) method.…”
Section: Methodsmentioning
confidence: 99%