Identification of Bluetongue Virus-specific Immunoglobulin E in Cattle

Anderson, Gary A.; Stott, Jeffrey L; Gershwin, Laurel J.; Osburn, Bennie

doi:10.1099/0022-1317-68-9-2509

Cited by 20 publications

(11 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in the present study, elevated plasma histamine &d not correlate with clinical disease. These results contrast with previous reports of experimental BT in cattle (STOTT et al, 1982;ANDERSON, 1984;ANDERSON et al, 1987). In those studies, calves were given multiple doses of inactivated BTV-17 in association with adjuvant (AlOH) and immunomodulatory drugs (levamisol and cimetidine) (STC) TT et al, 1982;ANDERSON, 1984).…”

Section: Discussioncontrasting

confidence: 56%

“…This phenomenon was also found to be a BTV-specific mechanism, since the infection of PBL-GRF with an unrelated reovirus did not result in histamine release. Since high levels of BTV-IgE have been repeatedly associated with BTV infections of cattle (ANDERSON, 1984;ANDERSON et al, 1987;O D~O N , 199l), these results permitted the speculation that the histamine release might have been an IgE-mediated reaction.…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Histamine and Eicosanoid Levels in Plasma and Peripheral Blood Leucocyte Cultures During Experimental Infection of Cattle with Bluetongue Virus Serotype 11

Odeón

Giri

Concha-Bermejillo

et al. 1997

Journal of Veterinary Medicine, Series B

Self Cite

View full text Add to dashboard Cite

Three calves were sensitized with three doses of inactivated B T V l l UC8 strain and then experimentally infected with the homologous virus. In addition, four BTV-seronegative heifers were also experimentally infected with BTV-11. Granulocyte rich fractions of peripheral blood leucocyte CpBL-GRF) cultures from BTV-sensitized/infected calves and from control unexposed cattle were exposed in uitm with BTV-11. Histamine, leukotriene (Lp C, and prostaglandin (PG) D, were assayed in supernatant fluids. Plasma histamine levels increased in BTV-infected heifers from 10.1 f 2 ng/ml at Day 0 to 23.1 f 6.6ng/ml at Day 12 following virus exposure. In addition, in this experimental group the concentration of PGF,, (mean 551.97 f 243.54pg/ml) increased significantly (P < 0.05) compared with control cattle (mean 467.3 f 73.9 pg/ml). Bluetongue virus induced hlstamine and I,TC, release after in vitm infection of PBL-GRF. Release of LTC, was sigruficantly ( I ' < 0.05) higher in PBL-GRF cultures from sensitized and control animals than in unexposed PBL-GRF cultures. In contrast to these results, PGDz was not released after BTV infection of PBL-GRF in vitro. The histamine release caused by BTV was virus-specific and mainly mediated by an immunological reaction, since the rclease was significantly reduced by removal of cell surface immunoglobuhns.

show abstract

Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 96%

Histamine and Eicosanoid Levels in Plasma and Peripheral Blood Leucocyte Cultures During Experimental Infection of Cattle with Bluetongue Virus Serotype 11

Odeón

Giri

Concha-Bermejillo

et al. 1997

Journal of Veterinary Medicine, Series B

Self Cite

View full text Add to dashboard Cite

show abstract

“…Prior to 1998, occasional short-lived incursions of BTV occurred in southern Europe (Spain, Portugal, Greece and Cyprus [62]). However, since 1998, at least eight distinct BTV strains from six different serotypes (types 1,2,4,8,9,16) have invaded Europe, including many northern European countries (serotype 8) 1 [79,85].…”

Section: Epidemiological Situation From 1900 To 2008mentioning

confidence: 99%

Section: Clinical Signsmentioning

confidence: 99%

“…Cattle, which are susceptible to BTV infection usually do not develop overt clinical signs, but they can manifest an IgE-mediated hypersensitivity reaction [1]. However, cattle are important in transmission, acting as reservoirs for the virus [1]. The strain of BTV serotype 8 that has invaded northern Europe is unusual because a large number of infected cattle also developed clinical signs [22].…”

Section: Clinical Signsmentioning

confidence: 99%

See 1 more Smart Citation

Bluetongue virus: virology, pathogenesis and immunity

et al. 2008

View full text Add to dashboard Cite

-Bluetongue (BT) virus, an orbivirus of the Reoviridae family encompassing 24 known serotypes, is transmitted to ruminants via certain species of biting midges (Culicoides spp.) and causes thrombo-hemorrhagic fevers mainly in sheep. During the 20th century, BTV was endemic in sub-tropical regions but in the last ten years, new strains of BTV (serotypes 1, 2, 4, 8, 9, 16) have appeared in Europe leading to a devastating disease in naive sheep and bovine herds (serotype 8). BTV enters into insect cells via the viral inner core VP7 protein and in mammalian cells via the external capsid VP2 haemagglutinin, which is the major determinant of BTV serotype and neutralization. BTV replicates in mononuclear phagocytes and endothelial cells where it induces expression of inflammatory cytokines as well as apoptosis. BTV can remain as nonreplicating entities concealed in erythrocytes for up to five months. Homologous protection against one BTV serotype involves neutralizing antibodies and T cell responses directed to the external VP2 and VP5 proteins, whereas heterologous protection is supported by T cells directed to the NS1 non structural protein and inner core proteins.

show abstract

The Role of Endothelial Cell-Derived Inflammatory and Vasoactive Mediators in the Pathogenesis of Bluetongue

et al. 2002

View full text Add to dashboard Cite

Bluetongue is an insect-transmitted disease of sheep and wild ruminants that is caused by bluetongue virus (BTV). Cattle are asymptomatic reservoir hosts of BTV. Infection of lung microvascular endothelial cells (ECs) is central to the pathogenesis of BTV infection of both sheep and cattle, but it is uncertain as to why sheep are highly susceptible to BTV-induced microvascular injury, whereas cattle are not. Thus, to better characterize the pathogenesis of bluetongue, the transcription of genes encoding a variety of vasoactive and inflammatory mediators was quantitated in primary ovine lung microvascular ECs (OLmVECs) exposed to BTV and/or inflammatory mediators. BTV infection of OLmVECs increased the transcription of genes encoding interleukin- (IL) 1 and IL-8, but less so IL-6, cyclooxygenase-2, and inducible nitric oxide synthase. In contrast, we previously have shown that transcription of genes encoding all of these same mediators is markedly increased in BTV-infected bovine lung microvascular ECs and that BTV-infected bovine ECs produce substantially greater quantities of prostacyclin than do sheep ECs. Thus, sheep and cattle were experimentally infected with BTV to further investigate the role of EC-derived vasoactive mediators in the pathogenesis of bluetongue. The ratio of thromboxane to prostacyclin increased during BTV infection of both sheep and cattle, but was significantly greater in sheep (P = 0.001). Increases in the ratio of thromboxane to prostacyclin, indicative of enhanced coagulation, coincided with the occurrence of clinical manifestations of bluetongue in BTV-infected sheep. The data suggest that inherent species-specific differences in the production and activities of EC-derived mediators contribute to the sensitivity of sheep to BTV-induced microvascular injury.

show abstract

Identification of Bluetongue Virus-specific Immunoglobulin E in Cattle

Cited by 20 publications

References 13 publications

Histamine and Eicosanoid Levels in Plasma and Peripheral Blood Leucocyte Cultures During Experimental Infection of Cattle with Bluetongue Virus Serotype 11

Histamine and Eicosanoid Levels in Plasma and Peripheral Blood Leucocyte Cultures During Experimental Infection of Cattle with Bluetongue Virus Serotype 11

Bluetongue virus: virology, pathogenesis and immunity

The Role of Endothelial Cell-Derived Inflammatory and Vasoactive Mediators in the Pathogenesis of Bluetongue

Contact Info

Product

Resources

About