Identification of c-myc promoter-binding protein and X-box binding protein 1 as interleukin-6 target genes in human multiple myeloma cells.

Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis

“…In normal PC development XBP1s is important in IL-6 up-regulation and secretion, 16 and previous experiments in myeloma have shown that XBP1 and IL-6 are dependent on each other. 24,25 However, the role of XBP1s in this experimental system has not been examined. Ongoing experiments are examining the role of XBP1/XBP1s within PCs and bone marrow stromal cells.…”

Standard and novel imaging methods for multiple myeloma: correlates with prognostic laboratory variables including gene expression profiling data

“…49 In myeloma cell lines, ENO1 has been identified as an IL-6 target gene. 51 Taken together, the unique association between MRI-FLs and PET-FLs and certain significant genes associated with cell cycle, DNA replication, or repair of DNA double-strand breaks (e.g. TRIP13, STK6) is in accordance with the wellrecognized chromosomal instability features in MM.…”

Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profile

“…Therefore, we hypothesize that KSHV pirated some host genes to help the virus direct B cell development toward plasma cells. It will be interesting to see whether vIL-6 is able to induce the expression of XBP-1, as is the case for its human counterpart (32). The block in the UPR (this article) and Ig production (6) seen in PEL cells could be because of KSHV infection.…”