2011
DOI: 10.1177/0300985810396106
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Identification of Cancer Stem Cells Derived From a Canine Lung Adenocarcinoma Cell Line

Abstract: Accumulating evidence supporting the cancer stem cell (CSC) hypothesis is based on the finding that tumors contain a small population of self-renewing cells that generate differentiated progeny and thereby contribute to tumor heterogeneity. CSCs are reported to exist in several human cancers, yet only a few reports demonstrate the existence of CSCs in primary lung cancer in dogs. In this study, the authors established a cancer cell line derived from a canine primary lung adenocarcinoma and identified a side po… Show more

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Cited by 27 publications
(22 citation statements)
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“…CLAC was used in this study . Adherent CLAC was cultured in Dulbecco's Modified Eagle's Medium (D'MEM) medium (Sigma–Aldrich, St. Louis, MO, USA), supplemented with 10% foetal bovine serum (FBS), MEM non‐essential amino acids (Life technologies, Carlsbad, CA, USA), 200 units mL −1 penicillin (Life technologies), 200 mg mL −1 streptomycin (Life technologies) and 2 mM l ‐glutamine (Life technologies) and maintained in a humidified atmosphere with 5% CO 2 at 37 °C.…”
Section: Methodsmentioning
confidence: 99%
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“…CLAC was used in this study . Adherent CLAC was cultured in Dulbecco's Modified Eagle's Medium (D'MEM) medium (Sigma–Aldrich, St. Louis, MO, USA), supplemented with 10% foetal bovine serum (FBS), MEM non‐essential amino acids (Life technologies, Carlsbad, CA, USA), 200 units mL −1 penicillin (Life technologies), 200 mg mL −1 streptomycin (Life technologies) and 2 mM l ‐glutamine (Life technologies) and maintained in a humidified atmosphere with 5% CO 2 at 37 °C.…”
Section: Methodsmentioning
confidence: 99%
“…The existence of canine CSCs/CICs have been reported in osteosarcoma, glioblastoma and mammary gland tumour . We previously established the canine lung adenocarcinoma cell (CLAC) line derived from primary canine lung adenocarcinoma and identified subpopulation exhibiting CSCs/CICs‐like properties from CLAC using the Hoechst 33342 dye‐based side population technique . The CSCs/CICs derived from CLAC was included at the ration of 0.075% and possess stemness property such as high tumourigenesis in vivo .…”
Section: Introductionmentioning
confidence: 99%
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“…CSCs have been identified in many human cancers, including skin, breast, liver, lung, and so on [1], [12], [14], [15]. Within a tumor, CSCs, which constitute a small portion of neoplastic cells, are defined by their capacity to produce new tumors.…”
Section: Introductionmentioning
confidence: 99%
“…CSCs have been identified in various human cancers, including those of the liver and lung [6,7]. Within a tumor, CSCs, which constitute a small portion of the neoplastic cells, are defined by their capacity to produce new tumors.…”
Section: Introductionmentioning
confidence: 99%