2020
DOI: 10.3390/genes11020121
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Identification of Caprine KRTAP28-1 and Its Effect on Cashmere Fiber Diameter

Abstract: The keratin-associated proteins (KAPs) are constituents of cashmere fibers and variation in many KAP genes (KRTAPs) has been found to be associated with fiber traits. The gene encoding the high-sulphur KAP28-1 has been described in sheep, but it has not been identified in the goat genome. In this study, a 255-bp open reading frame on goat chromosome 1 was identified using a search of similar sequence to ovine KRTAP28-1, and that would if transcribed and translated encode a high sulphur KAP. Based on the analys… Show more

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Cited by 9 publications
(10 citation statements)
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“…For example, given that KRTAPs are clustered, it is possible that the association with MFD detected for KRTAP27-1 may be due to linkage with other nearby KRTAPs. This is supported by the findings of similar phenotypic effects for KRTAP15-1 [5], KRTAP24-1 [6] and KRTAP28-1 [7], which are physically closed to KRTAP27-1 on the same chromosome.…”
Section: Discussionsupporting
confidence: 67%
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“…For example, given that KRTAPs are clustered, it is possible that the association with MFD detected for KRTAP27-1 may be due to linkage with other nearby KRTAPs. This is supported by the findings of similar phenotypic effects for KRTAP15-1 [5], KRTAP24-1 [6] and KRTAP28-1 [7], which are physically closed to KRTAP27-1 on the same chromosome.…”
Section: Discussionsupporting
confidence: 67%
“…This study confirms the identity of a caprine KAP gene on goat chromosome 1, which putatively encodes a HS-KAP protein that is most similar to the human KAP27-1 and the predicted caprine KRTAP27-1 sequences in Ensembl and GenBank. However, the Ensembl-predicted caprine KRTAP27-1 sequence ENSCHIG00000023347 located in the goat genome construct (ARS1:CM004562.1) at chromosome 1 position 3,966,193-3,973,677 contains two introns, with this not having been observed in the human KRTAP27-1 sequence or any of the other caprine or ovine KRTAP sequences reported to date, including caprine KRTAP8-2 [8], KRTAP15-1 [5], KRTAP20-1 [9], KRTAP20-2 [10], KRTAP24-1 [6] and KRTAP28-1 [7] or ovine KRTAP26-1 [11] and KRTAP22-1 [12]. This would suggest the construct may contain assembly errors.…”
Section: Discussionmentioning
confidence: 89%
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