Identification of categories at risk for high quality of life impairment in patients with vitiligo

Sampogna, Francesca; Raskovic, Desanka; Guerra, Liliana; Pedicelli, Cristina; Tabolli, Stefano; Leoni, Luca; Alessandroni, L.; Abeni, Damiano

doi:10.1111/j.1365-2133.2008.08678.x

Cited by 109 publications

(135 citation statements)

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“…Although vitiligo does not result in any restrictions on life expectancy or a patient's capacity to work, it can cause cosmetic disfigurement and may affect the psychological well being of patients 1,2 . The etiology of vitiligo remains unclear, but oxidative stress and the accumulation of free radicals have been proposed as important pathogenic mechanisms [3][4][5] .…”

Section: Introductionmentioning

confidence: 99%

Erythrocyte Malondialdehyde and Glutathione Levels in Vitiligo Patients

et al. 2010

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Background:Vitiligo is an acquired and progressive hypomelanotic disease that manifests as circumscribed depigmented patches on the skin. Although the precise mechanism remains to be elucidated, an imbalance of the oxidant/antioxidant system has been proposed as an important etiologic mechanism. Objective: The objective of this study was to evaluate the oxidant/antioxidant status of vitiligo patients at the erythrocyte level. Methods: Fifty-three vitiligo patients and 65 phototype-, age-, and sex-matched healthy controls were included in this study. Blood samples were collected from all subjects, and all patients were instructed to answer a questionnaire. Results: Erythrocyte levels of malondialdehyde (MDA) and glutathione (GSH) were measured. All patients were told to answer a questionnaire regarding their habitual behavior, including frequency of smoking and type of diet. We observed significantly lower levels of GSH in vitiligo patients, but the levels of MDA did not differ between patients and controls. Vitiligo patients who smoked showed significantly lower GSH levels compared to non-smoking patients, but the levels of MDA were unchanged between the 2 groups. Conclusion: From our results, we conclude that reduced erythrocytic or systemic GSH levels constitute a distinctive feature in vitiligo patients regardless of disease activity.

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Section: Introductionmentioning

confidence: 99%

Erythrocyte Malondialdehyde and Glutathione Levels in Vitiligo Patients

et al. 2010

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“…Sampogna et al [6] have reported significant correlation between quality of life levels and depressive symptoms and alexithymia. Unlike many other medical conditions, skin disorders are easily noticed by other people.…”

Section: Introductionmentioning

confidence: 99%

“…Unlike many other medical conditions, skin disorders are easily noticed by other people. Even though vitiligo does not directly cause a physical distress, it might cause discomfort as it disrupts the physical appearance and affects the psyche in a very negative way [6,40]. Studies in this field indicate that patients with vitiligo might experience low self-esteem [23] and depression [6,41].…”

Section: Introductionmentioning

confidence: 99%

“…It is commonly known that brain and skin develop from similar embryological origins and skin responses to stimuli have both physiological and psychological consequences [4]. Worldwide prevalence of vitiligo has been reported as 0.06-2.28% [5], and 50% of the cases are reported to be younger than 20 years old [6,7]. In a study conducted in Turkey, it was reported that 0.15-0.32% of patients that apply to dermatology outpatient units were diagnosed with vitiligo [8].…”

Section: Introductionmentioning

confidence: 99%

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